Expression pattern of nuclear p53 is unique in COS-1 cells

Jenq Chang Lee, Tsan Shen Lee, Hung Yiu Ho, Hsiao Chiang Hsueh, Wei Tai Huang, Yueh Ren Ho, Ming Derg Lai

Research output: Contribution to journalArticlepeer-review


As p53 is transcriptionally inactive in COS-1 cells, we felt it would be interesting to study the relative time course of expression of nuclear p53 and the onset of S phase. Our results indicated that the expression of nuclear p53 lagged behind the onset of S phase in COS-1 cells. In addition, rapid nuclear expression of p53, probably resulting from nuclear translocation, occurred immediately after the addition of serum into COS1 cells. No such phenomena were found in B104-1 and BHK cells.

Original languageEnglish
Pages (from-to)2705-2708
Number of pages4
JournalAnticancer research
Issue number5 A
Publication statusPublished - 1996 Sep

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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