Extravesical cryosurgical approach for VX2 bladder tumor in rabbits

Wen-Horng Yang, Monica Liebert, Roger E. Price, Douglas M. Cromeens, Johnny S. Lin, Barton H. Grossman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study characterized the VX2 bladder cancer model in rabbits and tested the feasibility of treating bladder cancer by extravesical cryosurgery. After the growth characteristics of the VX2 bladder tumor model were determined, the VX2 tumor was inoculated into rabbits at the dome of the bladder. One week later, three freeze/thaw cycles were followed by immediate surgical repair. The control group underwent a sham operation without freezing. When the VX2 tumor is injected into the bladder wall, invasion and central necrosis occurred within 1 week, lymphatic metastases by 2 weeks, and lung metastases by 3 weeks after inoculation. By 4 weeks, all control rabbits had large VX2 tumors in their bladders and advanced lung metastases. Nine of the ten rabbits in the cryosurgical group had mild to moderate degrees of lung metastases, and six of them had relatively small local recurrences. One rabbit had no tumor in the bladder and only microscopic lung metastasis. The extravesical approach to cryosurgery employing bladder inversion is well tolerated. Cryosurgery exhibits modest efficacy in treating local tumors and delaying lung metastasis in this aggressive tumor model.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalUrological Research
Volume29
Issue number5
DOIs
Publication statusPublished - 2001 Nov 22

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Urinary Bladder Neoplasms
Cryosurgery
Neoplasm Metastasis
Rabbits
Urinary Bladder
Lung
Neoplasms
Lymphatic Metastasis
Freezing
Necrosis
Recurrence
Control Groups
Growth

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Yang, W-H., Liebert, M., Price, R. E., Cromeens, D. M., Lin, J. S., & Grossman, B. H. (2001). Extravesical cryosurgical approach for VX2 bladder tumor in rabbits. Urological Research, 29(5), 345-349. https://doi.org/10.1007/s002400100204
Yang, Wen-Horng ; Liebert, Monica ; Price, Roger E. ; Cromeens, Douglas M. ; Lin, Johnny S. ; Grossman, Barton H. / Extravesical cryosurgical approach for VX2 bladder tumor in rabbits. In: Urological Research. 2001 ; Vol. 29, No. 5. pp. 345-349.
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Yang, W-H, Liebert, M, Price, RE, Cromeens, DM, Lin, JS & Grossman, BH 2001, 'Extravesical cryosurgical approach for VX2 bladder tumor in rabbits', Urological Research, vol. 29, no. 5, pp. 345-349. https://doi.org/10.1007/s002400100204

Extravesical cryosurgical approach for VX2 bladder tumor in rabbits. / Yang, Wen-Horng; Liebert, Monica; Price, Roger E.; Cromeens, Douglas M.; Lin, Johnny S.; Grossman, Barton H.

In: Urological Research, Vol. 29, No. 5, 22.11.2001, p. 345-349.

Research output: Contribution to journalArticle

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Yang W-H, Liebert M, Price RE, Cromeens DM, Lin JS, Grossman BH. Extravesical cryosurgical approach for VX2 bladder tumor in rabbits. Urological Research. 2001 Nov 22;29(5):345-349. https://doi.org/10.1007/s002400100204