Fabrication and characterization of CaP-coated nanotube arrays

Kuan Chen Kung, Jia Ling Chen, Yen Ting Liu, Tzer Min Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)


Modified anodization techniques have been shown to improve the biocompatibility of titanium. This study demonstrated the anodic formation of self-organized nanotube arrays on titanium from an electrolyte solution containing 1 M H3PO4 and 1 wt% hydrofluoric acid (HF). Our aim was to investigate the effects of sputter-deposited CaP on nanotube arrays. SEM images revealed a surface with uniform morphology and an average pore diameter of 29 nm. XRD results indicated that the phase of the nanotube arrays was amorphous. Electron spectroscopy for chemical analysis (ESCA) confirmed that the nanotube arrays were coated with calcium and phosphorus. Cell culture experiments using human osteosarcoma (HOS) cells demonstrated that the CaP/nanotube arrays had a pronounced effect on initial cell attachment as well as on the number of cells at 1, 7, and 14 days. Compared to as-polished titanium, the CaP/nanotube arrays accelerated cell proliferation, attachment, and spreading. Our results demonstrate the pronounced effects of CaP/nanotube arrays on the biological responses of HOS cells.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalMaterials Chemistry and Physics
Publication statusPublished - 2015 Mar 1

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Fabrication and characterization of CaP-coated nanotube arrays'. Together they form a unique fingerprint.

  • Cite this