TY - JOUR
T1 - Fabrication and characterization of CaP-coated nanotube arrays
AU - Kung, Kuan Chen
AU - Chen, Jia Ling
AU - Liu, Yen Ting
AU - Lee, Tzer Min
N1 - Funding Information:
The authors would like to thank the National Science Council of Taiwan for supporting this research under grant NSC 101-2221-E-006-061-MY3 .
Publisher Copyright:
© 2014 Published by Elsevier B.V.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Modified anodization techniques have been shown to improve the biocompatibility of titanium. This study demonstrated the anodic formation of self-organized nanotube arrays on titanium from an electrolyte solution containing 1 M H3PO4 and 1 wt% hydrofluoric acid (HF). Our aim was to investigate the effects of sputter-deposited CaP on nanotube arrays. SEM images revealed a surface with uniform morphology and an average pore diameter of 29 nm. XRD results indicated that the phase of the nanotube arrays was amorphous. Electron spectroscopy for chemical analysis (ESCA) confirmed that the nanotube arrays were coated with calcium and phosphorus. Cell culture experiments using human osteosarcoma (HOS) cells demonstrated that the CaP/nanotube arrays had a pronounced effect on initial cell attachment as well as on the number of cells at 1, 7, and 14 days. Compared to as-polished titanium, the CaP/nanotube arrays accelerated cell proliferation, attachment, and spreading. Our results demonstrate the pronounced effects of CaP/nanotube arrays on the biological responses of HOS cells.
AB - Modified anodization techniques have been shown to improve the biocompatibility of titanium. This study demonstrated the anodic formation of self-organized nanotube arrays on titanium from an electrolyte solution containing 1 M H3PO4 and 1 wt% hydrofluoric acid (HF). Our aim was to investigate the effects of sputter-deposited CaP on nanotube arrays. SEM images revealed a surface with uniform morphology and an average pore diameter of 29 nm. XRD results indicated that the phase of the nanotube arrays was amorphous. Electron spectroscopy for chemical analysis (ESCA) confirmed that the nanotube arrays were coated with calcium and phosphorus. Cell culture experiments using human osteosarcoma (HOS) cells demonstrated that the CaP/nanotube arrays had a pronounced effect on initial cell attachment as well as on the number of cells at 1, 7, and 14 days. Compared to as-polished titanium, the CaP/nanotube arrays accelerated cell proliferation, attachment, and spreading. Our results demonstrate the pronounced effects of CaP/nanotube arrays on the biological responses of HOS cells.
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U2 - 10.1016/j.matchemphys.2014.12.042
DO - 10.1016/j.matchemphys.2014.12.042
M3 - Article
AN - SCOPUS:84922326345
SN - 0254-0584
VL - 153
SP - 110
EP - 116
JO - Materials Chemistry and Physics
JF - Materials Chemistry and Physics
ER -