Fabrication of biodegradable polymer microneedle array via CO2 laser ablation

Kun Tse Tu, Chen Kuei Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Fabrication of biodegradable polylacticcoglycolic acid (PLGA) microneedle array through CO2 laser processing have been studied and analyzed. The high-Aspect-ratio microneedle mold can be obtained using the rapid and low-cost laser processing compared to conventional photolithography and dry etching processes. The laser processing on PDMS results in the problems of scorches and re-solidification. Here, we use the direct-write laser processing microneedle mold structure on PMMA and then perform two-casting PDMS process to form female microneedle mold. Then pour PLGA into PDMS female mold pre-treated by O2 plasma and drying in vacuum chamber. Finally, the complete PLGA microneedle array is released from the PDMS mold which is reusable. The polymer microneedle depth can be from hundreds of micrometers to millimeter that is related to the PMMA structure profile and determined by CO2 laser power and scanning speed. The modified integration of laser processing and molding process is maskless, simple, and low-cost for rapid prototyping.

Original languageEnglish
Title of host publication2015 IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages494-497
Number of pages4
ISBN (Electronic)9781467366953
DOIs
Publication statusPublished - 2015 Jul 1
Event10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015 - Xi'an, China
Duration: 2015 Apr 72015 Apr 11

Publication series

Name2015 IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015

Other

Other10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
CountryChina
CityXi'an
Period15-04-0715-04-11

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Hardware and Architecture

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