TY - GEN
T1 - Fabrication of biodegradable polymer microneedle array via CO2 laser ablation
AU - Tu, Kun Tse
AU - Chung, Chen Kuei
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Fabrication of biodegradable polylacticcoglycolic acid (PLGA) microneedle array through CO2 laser processing have been studied and analyzed. The high-Aspect-ratio microneedle mold can be obtained using the rapid and low-cost laser processing compared to conventional photolithography and dry etching processes. The laser processing on PDMS results in the problems of scorches and re-solidification. Here, we use the direct-write laser processing microneedle mold structure on PMMA and then perform two-casting PDMS process to form female microneedle mold. Then pour PLGA into PDMS female mold pre-treated by O2 plasma and drying in vacuum chamber. Finally, the complete PLGA microneedle array is released from the PDMS mold which is reusable. The polymer microneedle depth can be from hundreds of micrometers to millimeter that is related to the PMMA structure profile and determined by CO2 laser power and scanning speed. The modified integration of laser processing and molding process is maskless, simple, and low-cost for rapid prototyping.
AB - Fabrication of biodegradable polylacticcoglycolic acid (PLGA) microneedle array through CO2 laser processing have been studied and analyzed. The high-Aspect-ratio microneedle mold can be obtained using the rapid and low-cost laser processing compared to conventional photolithography and dry etching processes. The laser processing on PDMS results in the problems of scorches and re-solidification. Here, we use the direct-write laser processing microneedle mold structure on PMMA and then perform two-casting PDMS process to form female microneedle mold. Then pour PLGA into PDMS female mold pre-treated by O2 plasma and drying in vacuum chamber. Finally, the complete PLGA microneedle array is released from the PDMS mold which is reusable. The polymer microneedle depth can be from hundreds of micrometers to millimeter that is related to the PMMA structure profile and determined by CO2 laser power and scanning speed. The modified integration of laser processing and molding process is maskless, simple, and low-cost for rapid prototyping.
UR - http://www.scopus.com/inward/record.url?scp=84939528400&partnerID=8YFLogxK
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U2 - 10.1109/NEMS.2015.7147476
DO - 10.1109/NEMS.2015.7147476
M3 - Conference contribution
T3 - 2015 IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
SP - 494
EP - 497
BT - 2015 IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
Y2 - 7 April 2015 through 11 April 2015
ER -