Fabrication of cellhydroxyapatite nanocrystal composites assisted with layer-by-layer nanometer-sized extracellular matrix films on individual stem cells

Sushmita Saha, Takashi Yoshikai, Chun Yen Liu, Michiya Matsusaki, Xuebin B. Yang, Mitsuru Akashi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The ability to control cell function is one of the challenges for cell-based therapy in regenerative medicine. In this study, we describe a novel method to fabricate cellhydroxyapatite (HAp) nanocrystal composites to modulate cellular microenvironment. By preparation of layer-by-layer nanometer-sized extracellular matrix films onto cell surfaces, HAp nanocrystals were fabricated onto cell surfaces without cytotoxicity. This technology can modulate cellular functions such as adhesion, growth, and differentiation.

Original languageEnglish
Pages (from-to)1714-1716
Number of pages3
JournalChemistry Letters
Volume44
Issue number12
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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