Fabrication of Gd2O(CO3)2·H 2O/silica/gold hybrid particles as a bifunctional agent for MR imaging and photothermal destruction of cancer cells

Kuo Wei Hu, Fang Yu Jhang, Chia Hao Su, Chen Sheng Yeh

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Bifunctional Gd2O(CO3)2·H 2O/silica/Au hybrid particles were synthesized. The Gd 2O(CO3)2·H2O cores were decorated with a silica layer on the surface through the condensation of TEOS and reaction with APTES to produce Gd2O(CO3) 2·H2O/silica hybrid particles. The silica-coated particles were then conjugated with gold nanoparticles serving as seeds to react with HAuCl4 solution for the formation of Au shells leading to Gd2O(CO3)2·H2O/silica/Au hybrid particles. The thickness of the Au shells were set to 12, 26, 63 nm by adjusting the HAuCl4 amount. For in vitro MRI measurements, the T1-weighted performance was significantly affected by the Au shell thickness. The relaxivity r1 increased as the Au shell thickness decreased; 12 nm Au shell particles had the highest r1 value. The hybrid particles also showed the capability of absorbing near-infrared (NIR) radiation for photothermal destruction of cancer cells. It was found that the Au shell thickness also strongly influenced the NIR optical absorption and photothermal effect. At a fixed particle number, particles with a 63 nm Au shell exhibited the best photothermal performance. When the particle weight was fixed, 12 nm Au shell particles led to the optimum photothermal cancer destruction. Gd2O(CO3)2·H 2O/silica/Au hybrid particles demonstrated potential as a MR imaging and therapeutic agent.

Original languageEnglish
Pages (from-to)2147-2153
Number of pages7
JournalJournal of Materials Chemistry
Volume19
Issue number15
DOIs
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Materials Chemistry

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