Abstract
Bifunctional Gd2O(CO3)2·H 2O/silica/Au hybrid particles were synthesized. The Gd 2O(CO3)2·H2O cores were decorated with a silica layer on the surface through the condensation of TEOS and reaction with APTES to produce Gd2O(CO3) 2·H2O/silica hybrid particles. The silica-coated particles were then conjugated with gold nanoparticles serving as seeds to react with HAuCl4 solution for the formation of Au shells leading to Gd2O(CO3)2·H2O/silica/Au hybrid particles. The thickness of the Au shells were set to 12, 26, 63 nm by adjusting the HAuCl4 amount. For in vitro MRI measurements, the T1-weighted performance was significantly affected by the Au shell thickness. The relaxivity r1 increased as the Au shell thickness decreased; 12 nm Au shell particles had the highest r1 value. The hybrid particles also showed the capability of absorbing near-infrared (NIR) radiation for photothermal destruction of cancer cells. It was found that the Au shell thickness also strongly influenced the NIR optical absorption and photothermal effect. At a fixed particle number, particles with a 63 nm Au shell exhibited the best photothermal performance. When the particle weight was fixed, 12 nm Au shell particles led to the optimum photothermal cancer destruction. Gd2O(CO3)2·H 2O/silica/Au hybrid particles demonstrated potential as a MR imaging and therapeutic agent.
Original language | English |
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Pages (from-to) | 2147-2153 |
Number of pages | 7 |
Journal | Journal of Materials Chemistry |
Volume | 19 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2009 |
All Science Journal Classification (ASJC) codes
- General Chemistry
- Materials Chemistry