Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry

Chi Hsiang Lien, Wen Shuo Kuo, Keng Chi Cho, Chun Yu Lin, Yuan Deng Su, Lynn Ling-Huei Huang, Paul J. Campagnola, Chen Yuan Dong, Shean Jen Chen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.

Original languageEnglish
Pages (from-to)6260-6268
Number of pages9
JournalOptics Express
Volume19
Issue number7
DOIs
Publication statusPublished - 2011 Mar 28

Fingerprint

albumins
photochemical reactions
serums
nanorods
gold
microstructure
fabrication
photons
crosslinking
lasers
therapy
luminescence
damage
wavelengths
excitation

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

Cite this

Lien, Chi Hsiang ; Kuo, Wen Shuo ; Cho, Keng Chi ; Lin, Chun Yu ; Su, Yuan Deng ; Huang, Lynn Ling-Huei ; Campagnola, Paul J. ; Dong, Chen Yuan ; Chen, Shean Jen. / Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry. In: Optics Express. 2011 ; Vol. 19, No. 7. pp. 6260-6268.
@article{96188986d6c247238e29641bae1da483,
title = "Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry",
abstract = "In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30{\%}. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.",
author = "Lien, {Chi Hsiang} and Kuo, {Wen Shuo} and Cho, {Keng Chi} and Lin, {Chun Yu} and Su, {Yuan Deng} and Huang, {Lynn Ling-Huei} and Campagnola, {Paul J.} and Dong, {Chen Yuan} and Chen, {Shean Jen}",
year = "2011",
month = "3",
day = "28",
doi = "10.1364/OE.19.006260",
language = "English",
volume = "19",
pages = "6260--6268",
journal = "Optics Express",
issn = "1094-4087",
publisher = "The Optical Society",
number = "7",

}

Lien, CH, Kuo, WS, Cho, KC, Lin, CY, Su, YD, Huang, LL-H, Campagnola, PJ, Dong, CY & Chen, SJ 2011, 'Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry', Optics Express, vol. 19, no. 7, pp. 6260-6268. https://doi.org/10.1364/OE.19.006260

Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry. / Lien, Chi Hsiang; Kuo, Wen Shuo; Cho, Keng Chi; Lin, Chun Yu; Su, Yuan Deng; Huang, Lynn Ling-Huei; Campagnola, Paul J.; Dong, Chen Yuan; Chen, Shean Jen.

In: Optics Express, Vol. 19, No. 7, 28.03.2011, p. 6260-6268.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry

AU - Lien, Chi Hsiang

AU - Kuo, Wen Shuo

AU - Cho, Keng Chi

AU - Lin, Chun Yu

AU - Su, Yuan Deng

AU - Huang, Lynn Ling-Huei

AU - Campagnola, Paul J.

AU - Dong, Chen Yuan

AU - Chen, Shean Jen

PY - 2011/3/28

Y1 - 2011/3/28

N2 - In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.

AB - In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.

UR - http://www.scopus.com/inward/record.url?scp=79953221891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953221891&partnerID=8YFLogxK

U2 - 10.1364/OE.19.006260

DO - 10.1364/OE.19.006260

M3 - Article

VL - 19

SP - 6260

EP - 6268

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 7

ER -