@article{84174b10bed342af8852f258d961e744,
title = "Facile solid phase synthesis of octreotide analogs using p- carboxybenzaldehyde as a novel linker to anchor FMOC-threoninol to solid phase resins",
abstract = "A new procedure is described for the synthesis of octreotide and its analogs using p-carboxybenzaldehyde as a linker to anchor Fmoc-threoninol to solid phase resins. Fmoc-threoninol reacted with p-carboxybenzaldehyde to form Fmoc-threoninol p-carboxybenzacetal in 95% yield. The Fmoc-threoninol p- carboxybenzacetal was coupled to an amine-resin and octreotides were successfully synthesized with yields of 74-76%.",
author = "Wu, {Ying Ta} and Hsieh, {Hsing Pang} and Wu, {Chi Yu} and Yu, {Hui Ming} and Chen, {Shui Tein} and Wang, {Kung Tsung}",
note = "Funding Information: Support for this research provided by the National Science Council, Taiwan, is gratefully acknowledged. References 1. J. Pless, W. Bauer, U. Briner, W. Doepfner, P. Marbach, R. Maurer, T. J. Petcher, J. -C. Reubi, and J. Vonderscher, Scand. J. Gastroenterol., 1986, 21 suppl. 119, 54. 2. W. Bauer, U. Briner, W. Doepfner, R. Hailer, R. Huguenin, P. Marbach, T. J. Petcher, and J. Pless, Life Sci., 1982, 31, 1133. 3. D. Roemer, H. H. Buescher, R. C. Hill, J. Pless, W. Bauer, F. Cardinaux, A. Closse, D. Hauser, and R. Hugenin , Nature (London), 1977, 268,547. 4 D. Roemer and J. Pless, Life Sci., 1979, 24, 621. 5. G. Weckbecker, F. Raulf, B. Stolz, and C. Bruns, Pharmacol. Ther., 1993, 60, 245. 6. M. Mergler and R. Nyfeler, In Peptide, ed. C. H. Schneider & A. N. Eberle, 1992, ESCOM, 1993, p. 177. 7. W. B. Edwards, C. G. Fields, C. J. Anderson, T. S. Pajeau, M. J. Welch, and G. B. Fields, J. Med. Chem., 1994, 37, 3749. 8. Arano, Y.; Akizawa, H.; Uezono, T.; Akaji, K.; Ono, M.; Funakoshi, S.; Koizumi, M.; Yokoyama, A.; Kiso, Y.; Saji, H. Bioconjugate Chem. 1997, 8, 442-446. 9. Wenschuh, H.; Beyermann, M.; Haber, H.; Seydel, J.K.; Krause, E.; Bienert. M. J. Org. Chem. 1995, 60, 405-410. 10. M. A. Schmidt, R. R. Wilhelm, and A. Srinivasan, In Abstracts of the Fifteenth American Peptide Symposium, June 14-19,1997, Nashville, Tennessee, p. 2-109.",
year = "1998",
month = mar,
day = "26",
doi = "10.1016/S0040-4039(98)00044-6",
language = "English",
volume = "39",
pages = "1783--1784",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "13",
}