Factors affecting the statistical analysis of ultrasonic backscattering signals and imaging

Ya Ting Tsai, Jiue Jia Wu, Yi Hsun Lin, Shyh Hau Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statistical distribution of ultrasonic backscatter-ing signals has been demonstrated capable of characterizing variations of density and arrangement of scatterers in biological tissues. The statistical analysis of ultrasound signals has also found with less dependency on the attenuation effect. Yet, as the employed ultrasound frequency and pulse duration were increased, several factors could further affect the precise estimation of the statistical parameters. To further investigate the addressed issues, experiments were arranged and performed from tissue-mimicking phantoms and porcine livers. Various duty cycles, including 1, 3, 5, and 10%, of tone bursts at 1 KHz pulse repetition frequency corresponding to ultrasound frequencies of 3.5, 7.5, and 10 MHz were adjusted for driving the transducers. The tissue-mimicking phantoms were fabricated, which consisted of gelatin and glass beads of 16 and 64 scatter-ers/mm3 and those of porcine livers with either healthy or pathological fibrosis were obtained from local slaughter house. Various thickness of Silicone plates with the attenuation coefficient of 1.62 dB/mmžMHz were placed on the surface of objects to be measured. Nakagami statistical model, including shape parameter (Nakagami-m) and parametric imaging, was implemented to assess variations of the probability density function (PDF) estimated from the acquired ultrasonic backscattering signals. Results of phantoms indicated that the attenuation could significantly vary the shape of PDF of backscattered envelopes. Especially, large attenuation effect was found corresponding to those broader incident ultrasound bandwidths excited by the monocycle signal; whereas the effect is substantially reduced as the tone bursts were more than 3 cycles. Results of porcine livers indicated that the Nakagami-m increased with the increasing ultrasound frequencies and bandwidth, and that those associated PDFs were nearly pre-Rayleigh distributed. Both phantoms and porcine livers results consistently demonstrated that the use of 3 cycles tone bursts for exciting transducers may achieve the most appropriate performance to accommodate a tradeoff between attenuation effect and image resolution. Current study also verified that the operational modes of incident ultrasound need to be properly assured before that the statistical model may be further applied to clinical applications.

Original languageEnglish
Title of host publication16th Nordic-Baltic Conference on Biomedical Engineering - 16. NBC and 10. MTD 2014 Joint Conferences
EditorsMikael Persson, Henrik Mindedal
PublisherSpringer Verlag
Pages113-116
Number of pages4
ISBN (Electronic)9783319129662
DOIs
Publication statusPublished - 2015 Jan 1
Event16th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics and Medicinteknikdagarna Joint Conferences, NBC 2014 and MTD 2014 - Gothenburg, Sweden
Duration: 2014 Oct 142014 Oct 16

Publication series

NameIFMBE Proceedings
Volume48
ISSN (Print)1680-0737

Other

Other16th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics and Medicinteknikdagarna Joint Conferences, NBC 2014 and MTD 2014
CountrySweden
CityGothenburg
Period14-10-1414-10-16

Fingerprint

Backscattering
Statistical methods
Ultrasonics
Imaging techniques
Liver
Tissue
Probability density function
Transducers
Bandwidth
Silicones
Gelatin
Image resolution
Glass

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

Cite this

Tsai, Y. T., Wu, J. J., Lin, Y. H., & Wang, S. H. (2015). Factors affecting the statistical analysis of ultrasonic backscattering signals and imaging. In M. Persson, & H. Mindedal (Eds.), 16th Nordic-Baltic Conference on Biomedical Engineering - 16. NBC and 10. MTD 2014 Joint Conferences (pp. 113-116). (IFMBE Proceedings; Vol. 48). Springer Verlag. https://doi.org/10.1007/978-3-319-12967-9_31
Tsai, Ya Ting ; Wu, Jiue Jia ; Lin, Yi Hsun ; Wang, Shyh Hau. / Factors affecting the statistical analysis of ultrasonic backscattering signals and imaging. 16th Nordic-Baltic Conference on Biomedical Engineering - 16. NBC and 10. MTD 2014 Joint Conferences. editor / Mikael Persson ; Henrik Mindedal. Springer Verlag, 2015. pp. 113-116 (IFMBE Proceedings).
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abstract = "Statistical distribution of ultrasonic backscatter-ing signals has been demonstrated capable of characterizing variations of density and arrangement of scatterers in biological tissues. The statistical analysis of ultrasound signals has also found with less dependency on the attenuation effect. Yet, as the employed ultrasound frequency and pulse duration were increased, several factors could further affect the precise estimation of the statistical parameters. To further investigate the addressed issues, experiments were arranged and performed from tissue-mimicking phantoms and porcine livers. Various duty cycles, including 1, 3, 5, and 10{\%}, of tone bursts at 1 KHz pulse repetition frequency corresponding to ultrasound frequencies of 3.5, 7.5, and 10 MHz were adjusted for driving the transducers. The tissue-mimicking phantoms were fabricated, which consisted of gelatin and glass beads of 16 and 64 scatter-ers/mm3 and those of porcine livers with either healthy or pathological fibrosis were obtained from local slaughter house. Various thickness of Silicone plates with the attenuation coefficient of 1.62 dB/mmžMHz were placed on the surface of objects to be measured. Nakagami statistical model, including shape parameter (Nakagami-m) and parametric imaging, was implemented to assess variations of the probability density function (PDF) estimated from the acquired ultrasonic backscattering signals. Results of phantoms indicated that the attenuation could significantly vary the shape of PDF of backscattered envelopes. Especially, large attenuation effect was found corresponding to those broader incident ultrasound bandwidths excited by the monocycle signal; whereas the effect is substantially reduced as the tone bursts were more than 3 cycles. Results of porcine livers indicated that the Nakagami-m increased with the increasing ultrasound frequencies and bandwidth, and that those associated PDFs were nearly pre-Rayleigh distributed. Both phantoms and porcine livers results consistently demonstrated that the use of 3 cycles tone bursts for exciting transducers may achieve the most appropriate performance to accommodate a tradeoff between attenuation effect and image resolution. Current study also verified that the operational modes of incident ultrasound need to be properly assured before that the statistical model may be further applied to clinical applications.",
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Tsai, YT, Wu, JJ, Lin, YH & Wang, SH 2015, Factors affecting the statistical analysis of ultrasonic backscattering signals and imaging. in M Persson & H Mindedal (eds), 16th Nordic-Baltic Conference on Biomedical Engineering - 16. NBC and 10. MTD 2014 Joint Conferences. IFMBE Proceedings, vol. 48, Springer Verlag, pp. 113-116, 16th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics and Medicinteknikdagarna Joint Conferences, NBC 2014 and MTD 2014, Gothenburg, Sweden, 14-10-14. https://doi.org/10.1007/978-3-319-12967-9_31

Factors affecting the statistical analysis of ultrasonic backscattering signals and imaging. / Tsai, Ya Ting; Wu, Jiue Jia; Lin, Yi Hsun; Wang, Shyh Hau.

16th Nordic-Baltic Conference on Biomedical Engineering - 16. NBC and 10. MTD 2014 Joint Conferences. ed. / Mikael Persson; Henrik Mindedal. Springer Verlag, 2015. p. 113-116 (IFMBE Proceedings; Vol. 48).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Tsai YT, Wu JJ, Lin YH, Wang SH. Factors affecting the statistical analysis of ultrasonic backscattering signals and imaging. In Persson M, Mindedal H, editors, 16th Nordic-Baltic Conference on Biomedical Engineering - 16. NBC and 10. MTD 2014 Joint Conferences. Springer Verlag. 2015. p. 113-116. (IFMBE Proceedings). https://doi.org/10.1007/978-3-319-12967-9_31