Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Yung Chun Chuang, Yee-Shin Lin, Ching-Chuan Liu, Hsiao-Sheng Liu, Shu Hsing Liao, Ming Der Shi, Huan Yao Lei, Trai-Ming Yeh

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalJournal of the Formosan Medical Association
Volume112
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Dengue Virus
Fibrinolysis
Virus Diseases
Hemorrhage
Severe Dengue
Dengue
Viral Proteins
Hemostatics
Hemostasis
Autoantibodies
Cytokines

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chuang, Yung Chun ; Lin, Yee-Shin ; Liu, Ching-Chuan ; Liu, Hsiao-Sheng ; Liao, Shu Hsing ; Shi, Ming Der ; Lei, Huan Yao ; Yeh, Trai-Ming. / Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. In: Journal of the Formosan Medical Association. 2013 ; Vol. 112, No. 1. pp. 12-17.
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Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. / Chuang, Yung Chun; Lin, Yee-Shin; Liu, Ching-Chuan; Liu, Hsiao-Sheng; Liao, Shu Hsing; Shi, Ming Der; Lei, Huan Yao; Yeh, Trai-Ming.

In: Journal of the Formosan Medical Association, Vol. 112, No. 1, 01.01.2013, p. 12-17.

Research output: Contribution to journalReview article

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AU - Chuang, Yung Chun

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AU - Liu, Ching-Chuan

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AB - Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

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