Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Yung Chun Chuang, Yee Shin Lin, Ching Chuan Liu, Hsiao Sheng Liu, Shu Hsing Liao, Ming Der Shi, Huan Yao Lei, Trai Ming Yeh

Research output: Contribution to journalReview article

19 Citations (Scopus)


Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalJournal of the Formosan Medical Association
Issue number1
Publication statusPublished - 2013 Jan 1


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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