Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Yung Chun Chuang; Yee Shin Lin; Ching Chuan Liu; Hsiao Sheng Liu; Shu Hsing Liao; Ming Der Shi; Huan Yao Lei; Trai Ming Yeh

doi:10.1016/j.jfma.2012.10.013

Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Yung Chun Chuang
, Yee Shin Lin
, Ching Chuan Liu
, Hsiao Sheng Liu
, Shu Hsing Liao
, Ming Der Shi
, Huan Yao Lei
, Trai Ming Yeh

Research output: Contribution to journal › Review article › peer-review

41 Citations (Scopus)

Abstract

Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

Original language	English
Pages (from-to)	12-17
Number of pages	6
Journal	Journal of the Formosan Medical Association
Volume	112
Issue number	1
DOIs	https://doi.org/10.1016/j.jfma.2012.10.013
Publication status	Published - 2013 Jan

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

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10.1016/j.jfma.2012.10.013

Cite this

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title = "Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection",

abstract = "Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.",

author = "Chuang, \{Yung Chun\} and Lin, \{Yee Shin\} and Liu, \{Ching Chuan\} and Liu, \{Hsiao Sheng\} and Liao, \{Shu Hsing\} and Shi, \{Ming Der\} and Lei, \{Huan Yao\} and Yeh, \{Trai Ming\}",

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doi = "10.1016/j.jfma.2012.10.013",

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T1 - Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

AU - Chuang, Yung Chun

AU - Lin, Yee Shin

AU - Liu, Ching Chuan

AU - Liu, Hsiao Sheng

AU - Liao, Shu Hsing

AU - Shi, Ming Der

AU - Lei, Huan Yao

AU - Yeh, Trai Ming

PY - 2013/1

Y1 - 2013/1

N2 - Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

AB - Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

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DO - 10.1016/j.jfma.2012.10.013

M3 - Review article

C2 - 23332424

AN - SCOPUS:84872413363

SN - 0929-6646

VL - 112

SP - 12

EP - 17

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

IS - 1

ER -

Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Abstract

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