TY - JOUR
T1 - Factors related to metabolic parameters in medicated patients with major depressive disorder––a naturalistic study
AU - Lee, Chia Jung
AU - Lee, Lan Ting
AU - Tsai, Hsin Chun
AU - Chang, Wei Hung
AU - Lee, I. Hui
AU - Chen, Kao Chin
AU - Chang, Hui Hua
AU - Chen, Po See
AU - Yang, Yen Kuang
N1 - Funding Information:
This work was supported by the National Science Council of Taiwan ( NSC 93-2314-B-006-107 , NSC 97-2314-B-006-006-MY3 , and NSC 101-2314-B-006-065 ), the Department of Health, Taiwan ( DOH96-TD- d -113-041 ); Glaxo Smith Kline Taiwan Ltd. ; and National Cheng Kung University Hospital ( NCKUH-9903019 and NCKUH-10305006 ). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors do not have any disclosures, and the authors do not have any affiliation with or financial interest in any organization that might pose a conflict of interest. The authors are indebted to the research participants. The authors would also like to thank Ms. Tsai Hua Chang and Mr. Chien Ting Lin for their administrative support.
Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - The aim of this study was to examine the metabolic parameters, including body mass index (BMI), homeostasis model assessment-estimated insulin resistance (HOMA-IR), homeostasis model assessment-estimated pancreatic β-cell function (HOMA-β), and lipid plasma level, in medicated patients with major depressive disorder (MDD) and to assess factors related to metabolic parameters in patients with MDD. 121 patients with MDD and 63 controls were recruited. The Hamilton Depression Rating Scale (HDRS), Wisconsin Card Sorting Test (WCST), Continuous Performance Test (CPT), and Finger-Tapping Test (FTT), were administered. BMI, HOMA-IR, and HOMA-β were calculated as modifiable metabolic parameters. The FTT results and BMI in depressed patients were significantly poorer and lower, respectively, than those of the controls. However, no significant differences were noted between MDD patients and controls included metabolic parameters and other neuropsychological tests. Among depressed patients, higher BMI is significantly related with lower education, no tobacco use, and male. The result demonstrated metabolic parameters could be neutral among medicated patients with MDD, particularly in non-elderly Asian individuals. The deficits of psychomotor speed could be more prominent than other cognitive alterations in patient with MDD.
AB - The aim of this study was to examine the metabolic parameters, including body mass index (BMI), homeostasis model assessment-estimated insulin resistance (HOMA-IR), homeostasis model assessment-estimated pancreatic β-cell function (HOMA-β), and lipid plasma level, in medicated patients with major depressive disorder (MDD) and to assess factors related to metabolic parameters in patients with MDD. 121 patients with MDD and 63 controls were recruited. The Hamilton Depression Rating Scale (HDRS), Wisconsin Card Sorting Test (WCST), Continuous Performance Test (CPT), and Finger-Tapping Test (FTT), were administered. BMI, HOMA-IR, and HOMA-β were calculated as modifiable metabolic parameters. The FTT results and BMI in depressed patients were significantly poorer and lower, respectively, than those of the controls. However, no significant differences were noted between MDD patients and controls included metabolic parameters and other neuropsychological tests. Among depressed patients, higher BMI is significantly related with lower education, no tobacco use, and male. The result demonstrated metabolic parameters could be neutral among medicated patients with MDD, particularly in non-elderly Asian individuals. The deficits of psychomotor speed could be more prominent than other cognitive alterations in patient with MDD.
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U2 - 10.1016/j.psychres.2018.06.061
DO - 10.1016/j.psychres.2018.06.061
M3 - Article
C2 - 29986174
AN - SCOPUS:85049435616
SN - 0165-1781
VL - 268
SP - 28
EP - 33
JO - Psychiatry Research
JF - Psychiatry Research
ER -
