Failure of Thymidine Kinase-Negative Herpes Simplex Virus to Reactivate from Latency following Efficient Establishment

Shih Heng Chen, Angela Pearson, Donald M. Coen, Shun Hua Chen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate.

Original languageEnglish
Pages (from-to)520-523
Number of pages4
JournalJournal of Virology
Volume78
Issue number1
DOIs
Publication statusPublished - 2004 Jan 1

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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