Feasibility study of using high-frequency ultrasonic Nakagami imaging for characterizing the cataract lens in vitro

Po Hsiang Tsui, Chih Chung Huang, Chien Cheng Chang, Shyh Hau Wang, K. Kirk Shung

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

A cataract is a clouding of the crystalline lens that reduces the amount of incoming light and impairs visual perception. Phacoemulsification is the most common surgical method for treating advanced cataracts, and determining the optimal phacoemulsification energy is dependent on measuring the hardness of the lens. This study explored the feasibility of using an ultrasonic parametric image based on the Nakagami distribution to quantify the lens hardness. Young's modulus was measured in porcine lenses in which cataracts had been artificially induced. High-frequency ultrasound at 35 MHz was used to obtain the B-mode and Nakagami images of the cataract lenses. The averaged integrated backscatter and Nakagami parameters were also estimated in the region of interest. The experimental results show that the conventional B-scan and integrated backscatter are inadequate for quantifying the lens hardness, whereas Nakagami imaging allows different degrees of lens hardening to be distinguished both globally and locally based on the concentration of fiber coemption therein.

Original languageEnglish
Pages (from-to)6413-6425
Number of pages13
JournalPhysics in Medicine and Biology
Volume52
Issue number21
DOIs
Publication statusPublished - 2007 Nov 7

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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