TY - JOUR
T1 - Features of thiolated ligands promoting resistance to ligand exchange in self-assembled monolayers on gold nanoparticles
AU - Chen, Xinyue
AU - Qoutah, Wafaa W.
AU - Free, Paul
AU - Hobley, Jonathan
AU - Fernig, David G.
AU - Paramelle, David
N1 - Funding Information:
David Paramelle, Jonathan Hobley and Paul Free were supported by funds from A-STAR Institute of Materials Research and Engineering. Wafaa W. Qoutah acknowledges the support of the Ministry of Higher Education of Saudi Arabia and Xinyue Chen and David G. Fernig the support of the Cancer and Polio Research Fund and the North West Cancer Research Fund.
PY - 2012
Y1 - 2012
N2 - An important feature necessary for biological stability of gold nanoparticles is resistance to ligand exchange. Here, we design and synthesize self-assembled monolayers of mixtures of small ligands on gold nanoparticles promoting high resistance to ligand exchange. We use as ligands short thiolated peptidols, e.g. H-CVVVT-ol, and ethylene glycol terminated alkane thiols (HS-C 11-EG 4). We present a straightforward method to evaluate the relative stability of each ligand shell against ligand exchange with small thiolated molecules. The results show that a ligand with a 'thin' stem, such as HS-C 11-EG 4, is an important feature to build a highly packed self-assembled monolayer and provide high resistance to ligand exchange. The greatest resistance to ligand exchange was found for the mixed ligand shells of the pentapeptidols H-CAVLT-ol or H-CAVYT-ol and the ligand HS-C 11-EG 4 at 30:70 (mole/mole). Mixtures of ligands of very different diameters, such as the peptidol H-CFFFY-ol and the ligand HS-C 11-EG 4, provide only a slightly lower stability against ligand exchange. These ligand shells are thus likely to be suitable for long-term use in biological environments. The method developed here provides a rapid screening tool to identify nanoparticles likely to be suitable for use in biological and biomedical applications.
AB - An important feature necessary for biological stability of gold nanoparticles is resistance to ligand exchange. Here, we design and synthesize self-assembled monolayers of mixtures of small ligands on gold nanoparticles promoting high resistance to ligand exchange. We use as ligands short thiolated peptidols, e.g. H-CVVVT-ol, and ethylene glycol terminated alkane thiols (HS-C 11-EG 4). We present a straightforward method to evaluate the relative stability of each ligand shell against ligand exchange with small thiolated molecules. The results show that a ligand with a 'thin' stem, such as HS-C 11-EG 4, is an important feature to build a highly packed self-assembled monolayer and provide high resistance to ligand exchange. The greatest resistance to ligand exchange was found for the mixed ligand shells of the pentapeptidols H-CAVLT-ol or H-CAVYT-ol and the ligand HS-C 11-EG 4 at 30:70 (mole/mole). Mixtures of ligands of very different diameters, such as the peptidol H-CFFFY-ol and the ligand HS-C 11-EG 4, provide only a slightly lower stability against ligand exchange. These ligand shells are thus likely to be suitable for long-term use in biological environments. The method developed here provides a rapid screening tool to identify nanoparticles likely to be suitable for use in biological and biomedical applications.
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U2 - 10.1071/CH11432
DO - 10.1071/CH11432
M3 - Article
AN - SCOPUS:84863337515
VL - 65
SP - 266
EP - 274
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
SN - 0004-9425
IS - 3
ER -