TY - JOUR
T1 - Febrile convulsions increase risk of Tourette syndrome
AU - Tu, Yi Fang
AU - Lin, Cheng Li
AU - Lin, Chih Hao
AU - Huang, Chao Chin
AU - Sung, Fung Chang
AU - Kao, Chia Huang
N1 - Funding Information:
The study was supported by grants from the study hospital (DMR-102-014 and DMR-102-023); Health and welfare surcharge of tobacco products, China Medical University Hospital Cancer Research Center of Excellence ( MOHW103-TD-B-111-03 , Taiwan); and International Research-Intensive Centers of Excellence in Taiwan (I-RiCE) ( NSC101-2911-I-002-303 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding received for this study.
PY - 2014/9
Y1 - 2014/9
N2 - Purpose Febrile convulsion (FC) and Tourette syndrome (TS) are both common neurological disorders in infants and children. Both disorders share clinical similarities, such as paroxysmal symptoms with normal neurodevelopment and expected remission over time. This population-based study investigated the association between FC with TS during childhood neurodevelopment. Method We used the Taiwan National Health Insurance Research Database to conduct a retrospective cohort analysis on 1586 FC patients. A reference cohort of 6344 non-FC patients, matched for age, sex, urbanization level, parental occupation, and index year, was used for comparison. The risk of the occurrence of TS in FC patients was assessed using a Cox proportional hazard regression model. Results The overall incidence of TS was higher in the FC cohort than in the non-FC cohort (28.5 vs 13.9 per 10,000 person-years; adjusted hazard ratio = 1.91, 95% confidence interval = 1.32-2.75). The associated risk factors for FC patients to develop TS were boys, children living in rural areas, and children whose parents held blue-collar positions. Moreover, the risk of TS in FC patients rose from 0.89 to 16.0 (trend test P < 0.0001) when the frequency of FC-related medical visits increased from 1 to 2 times to more than 4 times. The adjusted hazard ratio for TS in related to FC-related medical visits was 1.02 (95% CI = 1.02-1.03) per one frequency increment. Conclusion FC may increase the risk of subsequent TS occurrence in children. Children who had frequent medical visits for FC were particularly vulnerable.
AB - Purpose Febrile convulsion (FC) and Tourette syndrome (TS) are both common neurological disorders in infants and children. Both disorders share clinical similarities, such as paroxysmal symptoms with normal neurodevelopment and expected remission over time. This population-based study investigated the association between FC with TS during childhood neurodevelopment. Method We used the Taiwan National Health Insurance Research Database to conduct a retrospective cohort analysis on 1586 FC patients. A reference cohort of 6344 non-FC patients, matched for age, sex, urbanization level, parental occupation, and index year, was used for comparison. The risk of the occurrence of TS in FC patients was assessed using a Cox proportional hazard regression model. Results The overall incidence of TS was higher in the FC cohort than in the non-FC cohort (28.5 vs 13.9 per 10,000 person-years; adjusted hazard ratio = 1.91, 95% confidence interval = 1.32-2.75). The associated risk factors for FC patients to develop TS were boys, children living in rural areas, and children whose parents held blue-collar positions. Moreover, the risk of TS in FC patients rose from 0.89 to 16.0 (trend test P < 0.0001) when the frequency of FC-related medical visits increased from 1 to 2 times to more than 4 times. The adjusted hazard ratio for TS in related to FC-related medical visits was 1.02 (95% CI = 1.02-1.03) per one frequency increment. Conclusion FC may increase the risk of subsequent TS occurrence in children. Children who had frequent medical visits for FC were particularly vulnerable.
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U2 - 10.1016/j.seizure.2014.05.005
DO - 10.1016/j.seizure.2014.05.005
M3 - Article
C2 - 24907027
AN - SCOPUS:84906319617
SN - 1059-1311
VL - 23
SP - 651
EP - 656
JO - Seizure
JF - Seizure
IS - 8
ER -