Febrile Seizures Impair Memory and cAMP Response-Element Binding Protein Activation

Ying Chao Chang, A-Min Huang, Yu-Min Kuo, Shan-Tair Wang, Yung Yee Chang, Chao-Ching Huang

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The long-term effects of brief but repetitive febrile seizures (FS) on memory have not been as thoroughly investigated as the impact of single and prolonged seizure in the developing brain. Using a heated-air FS paradigm, we subjected male rat pups to one, three, or nine episodes of brief FS on days 10 to 12 postpartum. Neither hippocampal neuronal damage nor apoptosis was noted within 72 hours after FS, nor was there significant hippocampal neuronal loss, aberrant mossy fiber sprouting, or altered seizure threshold to pentylenetetrazol in any FS group at adulthood. The adult rats subjected to nine episodes of early-life FS, however, showed long-term memory deficits as assessed by the Morris water maze. They also exhibited impaired intermediate and long-term memory but spared short-term memory in the inhibitory avoidance task. Three hours after inhibitory avoidance training, phosphorylation of cAMP response-element binding (CREB) protein in the hippocampus was significantly lower in nine-FS-group rats than in controls. Furthermore, rolipram administration, which activated the cAMP-CREB signaling pathway by inhibiting phosphodiesterase type IV, reversed the long-term memory deficits in nine-FS-group rats by enhancing hippocampal CREB phosphorylation. These results raise concerns about the long-term cognitive consequences of even brief frequently repetitive FS during early brain development.

Original languageEnglish
Pages (from-to)706-718
Number of pages13
JournalAnnals of Neurology
Volume54
Issue number6
DOIs
Publication statusPublished - 2003 Dec 1

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Cyclic AMP Response Element-Binding Protein
Febrile Seizures
Long-Term Memory
Memory Disorders
Response Elements
Phosphorylation
Type 4 Cyclic Nucleotide Phosphodiesterase
Rolipram
Pentylenetetrazole
Brain
Short-Term Memory
Postpartum Period
Epilepsy
Hippocampus
Seizures
Air
Apoptosis
Water

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

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title = "Febrile Seizures Impair Memory and cAMP Response-Element Binding Protein Activation",
abstract = "The long-term effects of brief but repetitive febrile seizures (FS) on memory have not been as thoroughly investigated as the impact of single and prolonged seizure in the developing brain. Using a heated-air FS paradigm, we subjected male rat pups to one, three, or nine episodes of brief FS on days 10 to 12 postpartum. Neither hippocampal neuronal damage nor apoptosis was noted within 72 hours after FS, nor was there significant hippocampal neuronal loss, aberrant mossy fiber sprouting, or altered seizure threshold to pentylenetetrazol in any FS group at adulthood. The adult rats subjected to nine episodes of early-life FS, however, showed long-term memory deficits as assessed by the Morris water maze. They also exhibited impaired intermediate and long-term memory but spared short-term memory in the inhibitory avoidance task. Three hours after inhibitory avoidance training, phosphorylation of cAMP response-element binding (CREB) protein in the hippocampus was significantly lower in nine-FS-group rats than in controls. Furthermore, rolipram administration, which activated the cAMP-CREB signaling pathway by inhibiting phosphodiesterase type IV, reversed the long-term memory deficits in nine-FS-group rats by enhancing hippocampal CREB phosphorylation. These results raise concerns about the long-term cognitive consequences of even brief frequently repetitive FS during early brain development.",
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Febrile Seizures Impair Memory and cAMP Response-Element Binding Protein Activation. / Chang, Ying Chao; Huang, A-Min; Kuo, Yu-Min; Wang, Shan-Tair; Chang, Yung Yee; Huang, Chao-Ching.

In: Annals of Neurology, Vol. 54, No. 6, 01.12.2003, p. 706-718.

Research output: Contribution to journalArticle

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