Fetuin-A as a predicator of sarcopenic left ventricular dysfunction

Wei Ting Chang, Wei-Chuan Tsai, Chih-Hsing Wu, Yen Wei Lee, Yun Lin Tai, Yi-Heng Li, Liang-Miin Tsai, Jyh Hong Chen, Ping-Yen Liu

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Abstract

Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541 asymptomatic elderly (≥65 years) patients. Compared with non-sarcopenic population, FetA levels were significantly elevated in the ninety-two (17%) patients (79 ± 6 years; male: 34.7%) diagnosed with sarcopenia (621.1 ± 140.7 vs. 697.3 ± 179.6 μg/ml, < 0.001). Sarcopenic left ventricular dysfunction (S-LVD) was defined by the coexistence of sarcopenia and systolic impairment (LVEF < 50%) and 23 (4.3%) of them met the criteria. Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD). Conversely, in the group without sarcopenia, FetA levels were similar regardless of systolic function. Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD. In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.

Original languageEnglish
Article number12078
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015 Jul 10

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alpha-2-HS-Glycoprotein
Sarcopenia
Left Ventricular Dysfunction
Body Composition
Logistic Models
Blood Pressure
Muscles

All Science Journal Classification (ASJC) codes

  • General

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Chang, Wei Ting ; Tsai, Wei-Chuan ; Wu, Chih-Hsing ; Lee, Yen Wei ; Tai, Yun Lin ; Li, Yi-Heng ; Tsai, Liang-Miin ; Chen, Jyh Hong ; Liu, Ping-Yen. / Fetuin-A as a predicator of sarcopenic left ventricular dysfunction. In: Scientific reports. 2015 ; Vol. 5.
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abstract = "Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541 asymptomatic elderly (≥65 years) patients. Compared with non-sarcopenic population, FetA levels were significantly elevated in the ninety-two (17{\%}) patients (79 ± 6 years; male: 34.7{\%}) diagnosed with sarcopenia (621.1 ± 140.7 vs. 697.3 ± 179.6 μg/ml, < 0.001). Sarcopenic left ventricular dysfunction (S-LVD) was defined by the coexistence of sarcopenia and systolic impairment (LVEF < 50{\%}) and 23 (4.3{\%}) of them met the criteria. Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD). Conversely, in the group without sarcopenia, FetA levels were similar regardless of systolic function. Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD. In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.",
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Fetuin-A as a predicator of sarcopenic left ventricular dysfunction. / Chang, Wei Ting; Tsai, Wei-Chuan; Wu, Chih-Hsing; Lee, Yen Wei; Tai, Yun Lin; Li, Yi-Heng; Tsai, Liang-Miin; Chen, Jyh Hong; Liu, Ping-Yen.

In: Scientific reports, Vol. 5, 12078, 10.07.2015.

Research output: Contribution to journalArticle

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AU - Chang, Wei Ting

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AU - Tai, Yun Lin

AU - Li, Yi-Heng

AU - Tsai, Liang-Miin

AU - Chen, Jyh Hong

AU - Liu, Ping-Yen

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