FGFR-related gene nou-darake restricts brain tissues to the head region of planarians

Francesc Cebrià, Chiyoko Kobayashi, Yoshihiko Umesono, Masumi Nakazawa, Katsuhiko Mineta, Kazuho Ikeo, Takashi Gojobori, Mari Itoh, Masanori Taira, Alejandro Sánchez Alvarado, Kiyokazu Agata

Research output: Contribution to journalArticlepeer-review

229 Citations (Scopus)


The study of planarian regeneration may help us to understand how we can rebuild organs and tissues after injury, disease or ageing. The robust regenerative abilities of planarians are based upon a population of totipotent stem cells (neoblasts), and among the organs regenerated by these animals is a well-organized central nervous system. In recent years, methodologies such as whole-mount in situ hybridizations and double-stranded RNA have been extended to planarians with the aim of unravelling the molecular basis of their regenerative capacities. Here we report the identification and characterization of nou-darake (ndk), a gene encoding a fibroblast growth factor receptor (FGFR)-like molecule specifically expressed in the head region of the planarian Dugesia japonica. Loss of function of ndk by RNA interference results in the induction of ectopic brain tissues throughout the body. This ectopic brain formation was suppressed by inhibition of two planarian FGFR homologues (FGFRI and FGFR2). Additionally, ndk inhibits FGF signalling in Xenopus embryos. The data suggest that ndk may modulate FGF signalling in stem cells to restrict brain tissues to the head region of planarians.

Original languageEnglish
Pages (from-to)620-624
Number of pages5
Issue number6907
Publication statusPublished - 2002 Oct 10

All Science Journal Classification (ASJC) codes

  • General


Dive into the research topics of 'FGFR-related gene nou-darake restricts brain tissues to the head region of planarians'. Together they form a unique fingerprint.

Cite this