Fibrolamellar hepatocellular carcinoma with a recurrence of classic hepatocellular carcinoma: A case report and review of oriental cases

Yu Chung Chang, Yuan Chang Dai, Nan Haw Chow

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A 72-year-old Chinese male, hepatitis B carrier, received a right hepatic trisegmentectomy in 1997 for fibrolamellar hepatocellular carcinoma. Serum alpha-fetoprotein was in the normal range until two years after the operation, a rapid increase to 241ng/mL occurred and computed tomography showed a 2-cm-sized recurrent nodule in the caudate lobe. Because computed tomography arterioportography showed additional multifocal nodules in the residual liver, transarterial embolization was performed. Four months after the first transarterial embolization, the caudate tumor grew to 6cm and serum alpha-fetoprotein increased to 6090ng/mL. Prior to the second transarterial embolization, this new hepatic lesion received a biopsy and showed a characteristic feature of classic hepatocellular carcinoma, which was different from the previous one. Four months after the second transarterial embolization, computed tomography showed no recurrent tumor and serum alpha-fetoprotein subsequently normalized. Twenty-two months after the first transarterial embolization, a 2.5-cm-sized tumor recurred again at the lateral segment. At this time, serum alpha-fetoprotein (3.6ng/mL) was not elevated. He received the third transarterial embolization and is still alive. Recurrence of fibrolamellar hepatocellular carcinoma after hepatic resection has been reported to be high, but a case report with a character of muticentric, multifocal, and metachronous recurrences of fibrolamellar and classic type hepatocellular carcinoma is very rare. This is the second case report in the literature.

Original languageEnglish
Pages (from-to)1637-1640
Number of pages4
JournalHepato-Gastroenterology
Volume50
Issue number53
Publication statusPublished - 2003 Sep 1

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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