Fine particulate matter-induced toxic effects in an animal model of caenorhabditis elegans

Meng Ching Chung, Ming Hsien Tsai, Danielle E. Que, Sayre J. Bongo, Wen Li Hsu, Lemmuel L. Tayo, Yi Hsien Lin, Sheng Lun Lin, Yan You Gou, Yi Chyun Hsu, Wen Che Hou, Kuo Lin Huang, How Ran Chao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Research has been focused on the health hazards of ambient PM2.5 related to humans. Many PM2.5 toxicity assessments using in vitro studies have focused on PM2.5-bounded hazardous pollutants. However, PM2.5 toxicity assessment by in vivo studies allow for better observation of the overall effects of PM2.5 exposure on entire organisms, making in vivo PM2.5 toxicity assessment relevant. The toxic effects of outdoor PM2.5, collected from National Pingtung University of Science and Technology (NPUST) and Linluo Junior High School (LJHS), Pingtung, Taiwan, on nematode Caenorhabditis elegans (C. elegans) were investigated. PM2.5 from NPUST and LJHS were found to be 4.5 and 2.5 µg Nm–3, respectively, which did not meet the standard. This levels of PM2.5 in Taiwan. For acute toxicity, no significant PM2.5 lethality on C. elegans was observed between NPUST and LJHS. PM2.5 from NPUST exhibited greater toxicity to lifespan (ageing), locomotion (head thrash), and reproduction (brood size) in the C. elegans animal models than that from LJHS; therefore, adverse effects could be correlated with PM2.5 concentrations. Prolonged exposure to PM2.5 led to more severe toxicity in nematodes as compared to acute exposure. In conclusion, this study suggests that the long-term adverse effects of ambient PM2.5 on environmental organisms should be carefully considered even when PM2.5 is at low levels. C. elegans is a sensitive animal model for the evaluation of PM2.5 ecotoxicity.

Original languageEnglish
Pages (from-to)1068-1078
Number of pages11
JournalAerosol and Air Quality Research
Volume19
Issue number5
DOIs
Publication statusPublished - 2019 May

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Particulate Matter
Poisons
Toxicity
particulate matter
Animals
toxicity
science and technology
animal
nematode
Health hazards
brood size
locomotion
toxic effect
Aging of materials
school
pollutant
exposure

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Pollution

Cite this

Chung, M. C., Tsai, M. H., Que, D. E., Bongo, S. J., Hsu, W. L., Tayo, L. L., ... Chao, H. R. (2019). Fine particulate matter-induced toxic effects in an animal model of caenorhabditis elegans. Aerosol and Air Quality Research, 19(5), 1068-1078. https://doi.org/10.4209/aaqr.2019.03.0127
Chung, Meng Ching ; Tsai, Ming Hsien ; Que, Danielle E. ; Bongo, Sayre J. ; Hsu, Wen Li ; Tayo, Lemmuel L. ; Lin, Yi Hsien ; Lin, Sheng Lun ; Gou, Yan You ; Hsu, Yi Chyun ; Hou, Wen Che ; Huang, Kuo Lin ; Chao, How Ran. / Fine particulate matter-induced toxic effects in an animal model of caenorhabditis elegans. In: Aerosol and Air Quality Research. 2019 ; Vol. 19, No. 5. pp. 1068-1078.
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abstract = "Research has been focused on the health hazards of ambient PM2.5 related to humans. Many PM2.5 toxicity assessments using in vitro studies have focused on PM2.5-bounded hazardous pollutants. However, PM2.5 toxicity assessment by in vivo studies allow for better observation of the overall effects of PM2.5 exposure on entire organisms, making in vivo PM2.5 toxicity assessment relevant. The toxic effects of outdoor PM2.5, collected from National Pingtung University of Science and Technology (NPUST) and Linluo Junior High School (LJHS), Pingtung, Taiwan, on nematode Caenorhabditis elegans (C. elegans) were investigated. PM2.5 from NPUST and LJHS were found to be 4.5 and 2.5 µg Nm–3, respectively, which did not meet the standard. This levels of PM2.5 in Taiwan. For acute toxicity, no significant PM2.5 lethality on C. elegans was observed between NPUST and LJHS. PM2.5 from NPUST exhibited greater toxicity to lifespan (ageing), locomotion (head thrash), and reproduction (brood size) in the C. elegans animal models than that from LJHS; therefore, adverse effects could be correlated with PM2.5 concentrations. Prolonged exposure to PM2.5 led to more severe toxicity in nematodes as compared to acute exposure. In conclusion, this study suggests that the long-term adverse effects of ambient PM2.5 on environmental organisms should be carefully considered even when PM2.5 is at low levels. C. elegans is a sensitive animal model for the evaluation of PM2.5 ecotoxicity.",
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Chung, MC, Tsai, MH, Que, DE, Bongo, SJ, Hsu, WL, Tayo, LL, Lin, YH, Lin, SL, Gou, YY, Hsu, YC, Hou, WC, Huang, KL & Chao, HR 2019, 'Fine particulate matter-induced toxic effects in an animal model of caenorhabditis elegans', Aerosol and Air Quality Research, vol. 19, no. 5, pp. 1068-1078. https://doi.org/10.4209/aaqr.2019.03.0127

Fine particulate matter-induced toxic effects in an animal model of caenorhabditis elegans. / Chung, Meng Ching; Tsai, Ming Hsien; Que, Danielle E.; Bongo, Sayre J.; Hsu, Wen Li; Tayo, Lemmuel L.; Lin, Yi Hsien; Lin, Sheng Lun; Gou, Yan You; Hsu, Yi Chyun; Hou, Wen Che; Huang, Kuo Lin; Chao, How Ran.

In: Aerosol and Air Quality Research, Vol. 19, No. 5, 05.2019, p. 1068-1078.

Research output: Contribution to journalArticle

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T1 - Fine particulate matter-induced toxic effects in an animal model of caenorhabditis elegans

AU - Chung, Meng Ching

AU - Tsai, Ming Hsien

AU - Que, Danielle E.

AU - Bongo, Sayre J.

AU - Hsu, Wen Li

AU - Tayo, Lemmuel L.

AU - Lin, Yi Hsien

AU - Lin, Sheng Lun

AU - Gou, Yan You

AU - Hsu, Yi Chyun

AU - Hou, Wen Che

AU - Huang, Kuo Lin

AU - Chao, How Ran

PY - 2019/5

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