@article{b92ec385a3814cdc95874df7f6092702,
title = "Fine particulate matter-induced toxic effects in an animal model of caenorhabditis elegans",
abstract = "Research has been focused on the health hazards of ambient PM2.5 related to humans. Many PM2.5 toxicity assessments using in vitro studies have focused on PM2.5-bounded hazardous pollutants. However, PM2.5 toxicity assessment by in vivo studies allow for better observation of the overall effects of PM2.5 exposure on entire organisms, making in vivo PM2.5 toxicity assessment relevant. The toxic effects of outdoor PM2.5, collected from National Pingtung University of Science and Technology (NPUST) and Linluo Junior High School (LJHS), Pingtung, Taiwan, on nematode Caenorhabditis elegans (C. elegans) were investigated. PM2.5 from NPUST and LJHS were found to be 4.5 and 2.5 µg Nm–3, respectively, which did not meet the standard. This levels of PM2.5 in Taiwan. For acute toxicity, no significant PM2.5 lethality on C. elegans was observed between NPUST and LJHS. PM2.5 from NPUST exhibited greater toxicity to lifespan (ageing), locomotion (head thrash), and reproduction (brood size) in the C. elegans animal models than that from LJHS; therefore, adverse effects could be correlated with PM2.5 concentrations. Prolonged exposure to PM2.5 led to more severe toxicity in nematodes as compared to acute exposure. In conclusion, this study suggests that the long-term adverse effects of ambient PM2.5 on environmental organisms should be carefully considered even when PM2.5 is at low levels. C. elegans is a sensitive animal model for the evaluation of PM2.5 ecotoxicity.",
author = "Chung, {Meng Ching} and Tsai, {Ming Hsien} and Que, {Danielle E.} and Bongo, {Sayre J.} and Hsu, {Wen Li} and Tayo, {Lemmuel L.} and Lin, {Yi Hsien} and Sheng-Lun Lin and Gou, {Yan You} and Hsu, {Yi Chyun} and Hou, {Wen Che} and Huang, {Kuo Lin} and Chao, {How Ran}",
note = "Funding Information: This study was supported by a grant from the Ministry of Science and Technology (MOST 106-2221-E-020-001-MY3). We acknowledge Mr. Ying-Jhih Syu from National Pingtung University of Science and Technology for assisting us to maintain and culture C. elegans. We also want to thank Miss Chia-Jung Yen from Kaohsiung Medical University for assisting us with the C. elegans experiments. We would also like to thank Dr. Chang-Shi Chen at National Cheng Kung University for his advice and help in attaining the C. elegans culture. The authors thanked the teachers and students in Linluo Junior High School for providing the air sampling site. Funding Information: This study was supported by a grant from the Ministry of Science and Technology (MOST106-2221-E-020-001-MY3). We acknowledge Mr. Ying-Jhih Syu from National Pingtung University of Science and Technology for assisting us to maintain and culture C. elegans. We also want to thank Miss Chia-Jung Yen from Kaohsiung Medical University for assisting us with the C. elegans experiments. We would also like to thank Dr. Chang-Shi Chen at National Cheng Kung University for his advice and help in attaining the C. elegans culture. The authors thanked the teachers and students in Linluo Junior High School for providing the air sampling site. Publisher Copyright: {\textcopyright} 2019, AAGR Aerosol and Air Quality Research. All rights reserved.",
year = "2019",
month = may,
doi = "10.4209/aaqr.2019.03.0127",
language = "English",
volume = "19",
pages = "1068--1078",
journal = "Aerosol and Air Quality Research",
issn = "1680-8584",
publisher = "AAGR Aerosol and Air Quality Research",
number = "5",
}