Finite element modeling of hyper-viscoelasticity of peripheral nerve ultrastructures

Cheng Tao Chang, Yu Hsing Chen, Chou-Ching Lin, Ming-Shaung Ju

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The mechanical characteristics of ultrastructures of rat sciatic nerves were investigated through animal experiments and finite element analyses. A custom-designed dynamic testing apparatus was used to conduct in vitro transverse compression experiments on the nerves. The optical coherence tomography (OCT) was utilized to record the cross-sectional images of nerve during the dynamic testing. Two-dimensional finite element models of the nerves were built based on their OCT images. A hyper-viscoelastic model was employed to describe the elastic and stress relaxation response of each ultrastructure of the nerve, namely the endoneurium, the perineurium and the epineurium. The first-order Ogden model was employed to describe the elasticity of each ultrastructure and a generalized Maxwell model for the relaxation. The inverse finite element analysis was used to estimate the material parameters of the ultrastructures. The results show the instantaneous shear modulus of the ultrastructures in decreasing order is perineurium, endoneurium, and epineurium. The FE model combined with the first-order Ogden model and the second-order Prony series is good enough for describing the compress-and-hold response of the nerve ultrastructures. The integration of OCT and the nonlinear finite element modeling may be applicable to study the viscoelasticity of peripheral nerve down to the ultrastructural level.

Original languageEnglish
Pages (from-to)1982-1987
Number of pages6
JournalJournal of Biomechanics
Volume48
Issue number10
DOIs
Publication statusPublished - 2015 Jul 16

Fingerprint

Viscoelasticity
Peripheral Nerves
Optical tomography
Optical Coherence Tomography
Finite Element Analysis
Testing
Stress relaxation
Elasticity
Sciatic Nerve
Rats
Animals
Elastic moduli
Experiments
Finite element method

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Cite this

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abstract = "The mechanical characteristics of ultrastructures of rat sciatic nerves were investigated through animal experiments and finite element analyses. A custom-designed dynamic testing apparatus was used to conduct in vitro transverse compression experiments on the nerves. The optical coherence tomography (OCT) was utilized to record the cross-sectional images of nerve during the dynamic testing. Two-dimensional finite element models of the nerves were built based on their OCT images. A hyper-viscoelastic model was employed to describe the elastic and stress relaxation response of each ultrastructure of the nerve, namely the endoneurium, the perineurium and the epineurium. The first-order Ogden model was employed to describe the elasticity of each ultrastructure and a generalized Maxwell model for the relaxation. The inverse finite element analysis was used to estimate the material parameters of the ultrastructures. The results show the instantaneous shear modulus of the ultrastructures in decreasing order is perineurium, endoneurium, and epineurium. The FE model combined with the first-order Ogden model and the second-order Prony series is good enough for describing the compress-and-hold response of the nerve ultrastructures. The integration of OCT and the nonlinear finite element modeling may be applicable to study the viscoelasticity of peripheral nerve down to the ultrastructural level.",
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Finite element modeling of hyper-viscoelasticity of peripheral nerve ultrastructures. / Chang, Cheng Tao; Chen, Yu Hsing; Lin, Chou-Ching; Ju, Ming-Shaung.

In: Journal of Biomechanics, Vol. 48, No. 10, 16.07.2015, p. 1982-1987.

Research output: Contribution to journalArticle

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