Flavonoids and ent-labdane diterpenoids from Andrographis paniculata and their antiplatelet aggregatory and vasorelaxing effects

Tian Shung Wu, Huei Jen Chern, Amooru Gangaiah Damu, Ping Chung Kuo, Chung Ren Su, E. Jian Lee, Chi Ming Teng

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Two new flavones, designated as andropaniculosin A (1) and andropaniculoside A (2), and 30 known compounds were isolated as a result of detailed chemical examination on the whole plants of Andrographis paniculata. Their structures have been elucidated mainly by 1D and 2D NMR, and MS spectroscopic methods. Among them, four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation. Furthermore, a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalJournal of Asian Natural Products Research
Volume10
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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