TY - JOUR
T1 - Flavonoids and ent-labdane diterpenoids from Andrographis paniculata and their antiplatelet aggregatory and vasorelaxing effects
AU - Wu, Tian Shung
AU - Chern, Huei Jen
AU - Damu, Amooru Gangaiah
AU - Kuo, Ping Chung
AU - Su, Chung Ren
AU - Lee, E. Jian
AU - Teng, Chi Ming
N1 - Funding Information:
The authors are grateful to the National Science Council, Taiwan (NSC 93-2113-M-006-001) for financial support for this research.
PY - 2008/1
Y1 - 2008/1
N2 - Two new flavones, designated as andropaniculosin A (1) and andropaniculoside A (2), and 30 known compounds were isolated as a result of detailed chemical examination on the whole plants of Andrographis paniculata. Their structures have been elucidated mainly by 1D and 2D NMR, and MS spectroscopic methods. Among them, four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation. Furthermore, a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta.
AB - Two new flavones, designated as andropaniculosin A (1) and andropaniculoside A (2), and 30 known compounds were isolated as a result of detailed chemical examination on the whole plants of Andrographis paniculata. Their structures have been elucidated mainly by 1D and 2D NMR, and MS spectroscopic methods. Among them, four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation. Furthermore, a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta.
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U2 - 10.1080/10286020701273627
DO - 10.1080/10286020701273627
M3 - Article
C2 - 18058376
AN - SCOPUS:36849007402
VL - 10
SP - 17
EP - 24
JO - Journal of Asian Natural Products Research
JF - Journal of Asian Natural Products Research
SN - 1028-6020
IS - 1
ER -