Flavonoids from Andrographis viscosula

Yerra Koteswara Rao, Amooru Gangaiah Damu, Alahari Janardhan Rao, Shanmuganathan Venkatesan, Ping Chung Kuo, Chunduri Venkata Rao, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Phytochemical investigation of the whole plant of Andrographis viscosula has led to the isolation of three new 2′-oxygenated flavonoids, (2R)-5-hydroxy-7,2′,3′-trimethoxyflavanone (1), 7,2′,5′- trimethoxyflavone (2), 5,7,2′,3′-tetramethoxyflavone (3), and eight known flavones, 5,7,2′-trimethoxyflavone (4), 5,7,2′,4′, 5′-pentamethoxyflavone (5), echioidinin (6), 5,2′,6′- trihydroxy-7-methoxyflavone (7), 5-hydroxy-7,2′-dimethoxyflavone (8), echioidin (9), echioidinin 5-O-glucoside (10), and 5,2′,6′- trihydroxy-7-methoxyflavone 2′-O-glucoside (11). The structures of 1-11 were elucidated by physical and spectral methods, including extensive 2D NMR studies. The presence of 2′-oxygenated flavonoids is apparently restricted to Andrographis species in Acanthaceae. Therefore, 2′-oxygenated flavonoids are regarded as chemotaxonomic markers of Andrographis genus in the Acanthaceae family.

Original languageEnglish
Pages (from-to)1374-1376
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume51
Issue number12
DOIs
Publication statusPublished - 2003 Dec

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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