Fluorescent polymeric micelles with aggregation-induced emission properties for monitoring the encapsulation of doxorubicin

Jen Ing Chen, Wen Chung Wu

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

A new type of fluorescent polymeric micelles is developed by self-assembly from a series of amphiphilic block copolymers, poly(ethylene glycol)-b-poly[styrene-co-(2-(1,2,3,4,5-pentaphenyl-1H-silol-1-yloxy)ethyl methacrylate)] [PEG-b-P(S-co-PPSEMA)]. Their capability of loading doxorubicin (DOX) is investigated by monitoring the loading content, encapsulation efficiency, and photophysical properties of micelles. Förster resonance energy transfer from PPSEMA to DOX is observed in DOX-loaded micelles, which can serve as an indication of successful encapsulation of DOX in these micelles. The application of this new type of fluorescent polymeric micelles as a fluorescent probe and an anticancer drug carrier simultaneously is explored by studying the intracellular uptake of DOX-loaded micelles.

Original languageEnglish
Pages (from-to)623-632
Number of pages10
JournalMacromolecular Bioscience
Volume13
Issue number5
DOIs
Publication statusPublished - 2013 May 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Fluorescent polymeric micelles with aggregation-induced emission properties for monitoring the encapsulation of doxorubicin'. Together they form a unique fingerprint.

Cite this