Force-mediated dissociation of proteoglycan aggregate in articular cartilage

Xuhui Liu, Jian Q. Sun, Michael H. Heggeness, Ming-Long Yeh, Zong Ping Luo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Proteoglycan aggregate is the primary component in articular cartilage responsible for resisting compressive loading. It consists of a core molecule of hyaluronan and a number of side chains of aggrecan bound to hyaluronan non-covalently. The loss of aggrecan from articular cartilage is considered to be a major factor in the development of osteoarthritis. Though enzymatic digestion of aggrecan is believed to be responsible for the release of aggrecan from osteoarthritic cartilage, other mechanisms, such as direct force-mediated detachment of aggrecan from hyaluronan may also be involved. In this study, the rupture force of the single bond between hyaluronan and aggrecan in articular cartilage was directly quantified using experimental measurement and Monte Carlo simulation. Low rupture force of this bond, as determined in this study suggested a possible direct force-mediated detachment of aggrecan from proteoglycan aggregate in osteoarthritic cartilage.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalBiorheology
Volume43
Issue number3-4
Publication statusPublished - 2006

Fingerprint

Aggrecans
Articular Cartilage
Proteoglycans
Hyaluronic Acid
Cartilage
Rupture
Osteoarthritis
Digestion

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Liu, X., Sun, J. Q., Heggeness, M. H., Yeh, M-L., & Luo, Z. P. (2006). Force-mediated dissociation of proteoglycan aggregate in articular cartilage. Biorheology, 43(3-4), 183-190.
Liu, Xuhui ; Sun, Jian Q. ; Heggeness, Michael H. ; Yeh, Ming-Long ; Luo, Zong Ping. / Force-mediated dissociation of proteoglycan aggregate in articular cartilage. In: Biorheology. 2006 ; Vol. 43, No. 3-4. pp. 183-190.
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Liu, X, Sun, JQ, Heggeness, MH, Yeh, M-L & Luo, ZP 2006, 'Force-mediated dissociation of proteoglycan aggregate in articular cartilage', Biorheology, vol. 43, no. 3-4, pp. 183-190.

Force-mediated dissociation of proteoglycan aggregate in articular cartilage. / Liu, Xuhui; Sun, Jian Q.; Heggeness, Michael H.; Yeh, Ming-Long; Luo, Zong Ping.

In: Biorheology, Vol. 43, No. 3-4, 2006, p. 183-190.

Research output: Contribution to journalArticle

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