Four years of lamivudine treatment in Chinese patients with chronic hepatitis B

Ting Tsung Chang, Ching Lung Lai, Rong Nan Chien, Richard Guan, Seng Gee Lim, Chuan Mo Lee, Keng Yeen Ng, Graham J. Nicholls, Julie C. Dent, Nancy W.Y. Leung

Research output: Contribution to journalArticle

217 Citations (Scopus)


Background and Aims: This study assessed the efficacy and safety of up to 4 years of lamivudine treatment and the clinical relevance of the emergence of YMDD-variant hepatitis B virus (HBV). Methods: Fifty-eight Chinese adult patients with chronic hepatitis B (CHB) were randomized to lamivudine 100 mg/day for up to 5 years and were monitored for YMDD-variant HBV, hepatitis B e antigen (HBeAg) seroconversion (loss of HBeAg and detectable antibody to HBeAg) and serum alanine aminotransferase (ALT) concentrations. Four-year data are reported here. Results: The rate of HBeAg seroconversion increased with extended therapy and also with higher baseline ALT concentrations. YMDD-variant HBV was detected in 67% (39/58) of patients at some point during treatment. After 4 years, a total of 47% (27/58) of patients achieved HBeAg seroconversion. Thirty-three per cent (13/39) of patients with YMDD-variant HBV achieved HBeAg seroconversion; this increased to 57% (8/14) in patients with moderately elevated (>2-5 × upper limit of normal) pre-treatment ALT concentrations. The proportion of patients that achieved normal serum ALT increased from 29% (17/58) at baseline to 69% (31/45) following 4 years of treatment. That included 68% (23/34) of patients with YMDD-variant HBV and 73% (8/11) of those without the variant. All patients receiving lamivudine had reduced serum concentrations of HBV-DNA compared with baseline, despite the emergence of YMDD-variant HBV in 39 patients. Lamivudine was generally well tolerated; there was little change in the number or type of drug-related adverse events in the fourth year of the study. Conclusions: Despite the emergence of YMDD-variant HBV, Chinese patients showed increased HBeAg seroconversion and improvement in ALT levels with an increased duration of treatment with lamivudine.

Original languageEnglish
Pages (from-to)1276-1282
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number11
Publication statusPublished - 2004 Nov

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Four years of lamivudine treatment in Chinese patients with chronic hepatitis B'. Together they form a unique fingerprint.

  • Cite this

    Chang, T. T., Lai, C. L., Chien, R. N., Guan, R., Lim, S. G., Lee, C. M., Ng, K. Y., Nicholls, G. J., Dent, J. C., & Leung, N. W. Y. (2004). Four years of lamivudine treatment in Chinese patients with chronic hepatitis B. Journal of Gastroenterology and Hepatology (Australia), 19(11), 1276-1282.