@article{bb05a3b76dd148898f27b23025781519,
title = "FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis",
abstract = "Wnt/β-catenin signaling is essential for stem cell regulation and tumorigenesis, but its molecular mechanisms are not fully understood. Here, we report that FoxM1 is a downstream component of Wnt signaling and is critical for β-catenin transcriptional function in tumor cells. Wnt3a increases the level and nuclear translocation of FoxM1, which binds directly to β-catenin and enhances β-catenin nuclear localization and transcriptional activity. Genetic deletion of FoxM1 in immortalized neural stem cells abolishes β-catenin nuclear localization. FoxM1 mutations that disrupt the FoxM1-β-catenin interaction or FoxM1 nuclear import prevent β-catenin nuclear accumulation in tumor cells. FoxM1-β-catenin interaction controls Wnt target gene expression, is required for glioma formation, and represents a mechanism for canonical Wnt signaling during tumorigenesis.",
author = "Nu Zhang and Ping Wei and Aihua Gong and Chiu, \{Wen Tai\} and Lee, \{Hsueh Te\} and Howard Colman and He Huang and Jianfei Xue and Mingguang Liu and Yong Wang and Raymond Sawaya and Keping Xie and Yung, \{W. K.Alfred\} and Medema, \{Ren{\'e} H.\} and Xi He and Suyun Huang",
note = "Funding Information: We thank Bert Vogelstein for pBV-TBE1/2-luc, pBV-TBE1m/2m-luc, and Myc-TCF; Eric R. Fearon for DN-TCF4 and pcDNA3-S33Y β-catenin; Robert A. Weinberg for the PLKO.1-sh-β-catenin lentivirus vector; Robert H. Costa and Pradip Raychaudhuri for FoxM1 fl/fl mice; Ganesh Rao for mouse high-grade glioma specimens; and Frederick F. Lang for MD7-2, MD6-27, and mouse GIC neurospheres. We also thank Karen Muller and David Wildrick for editorial comments. This work was supported in part by the National Cancer Institute (grants RO1CA157933, RO1CA152309, R21CA152623, and P50-CA-127001) and by a Multidisciplinary Research Program grant at M. D. Anderson. H.H. and X.H. are partly supported by National Institutes of Health grant RO1GM074241 to X.H., who was a scholar of the Leukemia and Lymphoma Society. ",
year = "2011",
month = oct,
day = "18",
doi = "10.1016/j.ccr.2011.08.016",
language = "English",
volume = "20",
pages = "427--442",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",
}