Free radical cyclization reactions of alkylsulfonyl and alkylthio substituted aromatic amide derivatives

Yi Lung Wu, Che Ping Chuang, Pey Yun Lin

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Free radical cyclization reactions of alkylsulfonyl and alkylthio substituted aromatic amide derivatives are described. Carbon radicals can be generated efficiently from the sulfonyl radical induced reaction of allylsulfones or the oxidation of carbonyl compounds with manganese(III) acetate. These radicals undergo either 6-membered or 5-membered ring cyclization onto the aromatic ring effectively and provide synthetically useful methods for the syntheses of quinolinones, indolinones and indolinediones. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)6209-6217
Number of pages9
JournalTetrahedron
Volume56
Issue number34
DOIs
Publication statusPublished - 2000 Aug 18

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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