Frequencies of fetal nucleated red blood cells in maternal blood during different stages of gestation

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Nucleated red blood cells (NRBCs) isolated by a triple density gradient from 100 ml peripheral blood samples of 100 pregnant women and 30 women post-partum were subjected to morphological analysis and PCR quantitation. The number of NRBCs steadily increased from 5.3 (frequency: 2.4 x 10-7) in early gestation to 98.2 (frequency: 4.2 x 10-6) near term. The number of male cells increased from 6 (frequency: 2.7 x 10-7) in early gestation to a peak of 31 (frequency: 1.48 x 10-6) in the second trimester, and slightly decreased to 27 (frequency: 1.31 x 10-6) near term. Both NRBCs and male fetal cells rapidly disappeared after delivery. The result implies that a significant proportion of NRBCs in maternal blood are of fetal origin before 24 weeks of gestation while in late gestation the majority of NRBCs may be of maternal origin.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalFetal Diagnosis and Therapy
Volume13
Issue number6
DOIs
Publication statusPublished - 1998 Dec 1

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Frequencies of fetal nucleated red blood cells in maternal blood during different stages of gestation'. Together they form a unique fingerprint.

  • Cite this