Frequency multiplexed intensity modulated diffuse reflectance system for quantification of tissue and arterial oxygen saturation

Po Jian Liang, Sheng Hao Tseng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pulse oximeter has been a widely used instrument in hospitals or household for measuring arterial oxygen saturation value. Its annual global market value has exceeded USD 1 billion and is still growing. There are two main shortcomings in most pulse oximeters on the market: 1. database based algorithm limits the range of precision, and 2. incapable of measuring tissue oxygen saturation related to local tissue oxygen exchange condition. We developed a 3-wavelength frequency multiplexed intensity modulated diffuse reflectance system in which the modulation frequencies of the 3 light sources are different so that the light reflectance at the 3 wavelengths can be collected by the detector simultaneously. This allows us achieving determination of absorption and reduced scattering coefficients at the 3 wavelengths of the exactly same instant of time and this can lead to accurate quantification of tissue and arterial oxygen saturations. This technique works in conjunction with a photon diffusion equation and does not need to build a database in advance to calculate arterial oxygen saturation. In addition, capability of this system in measuring tissue oxygen saturation would facilitate swift monitoring of local tissue blood circulation.

Original languageEnglish
Title of host publicationDiffuse Optical Spectroscopy and Imaging VII
EditorsHamid Dehghani, Heidrun Wabnitz
PublisherSPIE
ISBN (Electronic)9781510628410
DOIs
Publication statusPublished - 2019 Jan 1
EventDiffuse Optical Spectroscopy and Imaging VII 2019 - Munich, Germany
Duration: 2019 Jun 232019 Jun 25

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11074
ISSN (Print)1605-7422

Conference

ConferenceDiffuse Optical Spectroscopy and Imaging VII 2019
CountryGermany
CityMunich
Period19-06-2319-06-25

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Liang, P. J., & Tseng, S. H. (2019). Frequency multiplexed intensity modulated diffuse reflectance system for quantification of tissue and arterial oxygen saturation. In H. Dehghani, & H. Wabnitz (Eds.), Diffuse Optical Spectroscopy and Imaging VII [110742H] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11074). SPIE. https://doi.org/10.1117/12.2526611