TY - JOUR
T1 - From Microenvironment Remediation to Novel Anti-Cancer Strategy
T2 - The Emergence of Zero Valent Iron Nanoparticles
AU - Wu, Ya Na
AU - Yang, Li Xing
AU - Wang, Pei Wen
AU - Braet, Filip
AU - Shieh, Dar Bin
N1 - Funding Information:
Funding: This work was supported by the Center of Applied Nanomedicine, National Cheng Kung University, Featured Areas Research Center Program, Higher Education Sprout Project of the Taiwan Ministry of Education (MOE), and by grants from the Taiwan Ministry of Science and Technology (MOST 108-2314-B-006 -009 -MY3; MOST 110-2314-B-006-117-MY3). We also like to thank the Taiwan Ministry of Science and Technology for a National Core Facility for Biopharmaceuticals Project (MOST 110-2740-B-006-003) to Shang-Rung Wu as well as the postdoctoral fellowship (MOST 110-2811-B-006-531) to Y.W. for supporting our work.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1
Y1 - 2022/1
N2 - Accumulated studies indicate that zero-valent iron (ZVI) nanoparticles demonstrate endogenous cancer-selective cytotoxicity, without any external electric field, lights, or energy, while sparing healthy non-cancerous cells in vitro and in vivo. The anti-cancer activity of ZVI-based nanoparticles was anti-proportional to the oxidative status of the materials, which indicates that the elemental iron is crucial for the observed cancer selectivity. In this thematic article, distinctive endogenous anti-cancer mechanisms of ZVI-related nanomaterials at the cellular and molecular levels are reviewed, including the related gene modulating profile in vitro and in vivo. From a material science perspective, the underlying mechanisms are also analyzed. In summary, ZVI-based nanomaterials demonstrated prominent potential in precision medicine to modulate both programmed cell death of cancer cells, as well as the tumor microenvironment. We believe that this will inspire advanced anti-cancer therapy in the future.
AB - Accumulated studies indicate that zero-valent iron (ZVI) nanoparticles demonstrate endogenous cancer-selective cytotoxicity, without any external electric field, lights, or energy, while sparing healthy non-cancerous cells in vitro and in vivo. The anti-cancer activity of ZVI-based nanoparticles was anti-proportional to the oxidative status of the materials, which indicates that the elemental iron is crucial for the observed cancer selectivity. In this thematic article, distinctive endogenous anti-cancer mechanisms of ZVI-related nanomaterials at the cellular and molecular levels are reviewed, including the related gene modulating profile in vitro and in vivo. From a material science perspective, the underlying mechanisms are also analyzed. In summary, ZVI-based nanomaterials demonstrated prominent potential in precision medicine to modulate both programmed cell death of cancer cells, as well as the tumor microenvironment. We believe that this will inspire advanced anti-cancer therapy in the future.
UR - http://www.scopus.com/inward/record.url?scp=85122155596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85122155596&partnerID=8YFLogxK
U2 - 10.3390/pharmaceutics14010099
DO - 10.3390/pharmaceutics14010099
M3 - Review article
AN - SCOPUS:85122155596
SN - 1999-4923
VL - 14
JO - Pharmaceutics
JF - Pharmaceutics
IS - 1
M1 - 99
ER -