Fruit and vegetable intakes are associated with lower risk of colorectal adenomas

Huiyun Wu, Qi Dai, Martha J. Shrubsole, Reid M. Ness, David Schlundt, Walter E. Smalley, Heidi Chen, Ming Li, Yu Shyr, Wei Zheng

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Many phytochemicals in fruits and vegetables have been shown to have cancer-inhibitory effects in animal studies. These effects on cancer, however, have not been clearly demonstrated in human studies. This study investigated the association between fruit and vegetable intakes and the risk of adenomatous polyps. Participants were part of the Tennessee Colorectal Polyp Study. Eligible participants aged 40-75 y were recruited from patients undergoing colonoscopy at 2 medical centers in Nashville, Tennessee from 2003 to 2005. Cases had at least one adenoma and controls were polyp free. Dietary intake was assessed using a self-administered FFQ. Associations between dietary intakes and adenoma risk were evaluated using unconditional logistic regression with restricted cubic function spline. In multivariate analyses of 764 cases and 1517 controls, increased intakes of total fruits, berries, fruit juice, and green leafy vegetables were associated with reduced adenoma risk. The odds ratio for upper tertile intake compared with lower was 0.66 (95% Cl = 0.51-0.86) for total fruits, 0.64 (95% Cl = 0.47-0.87) for berries, 0.72 (95% Cl = 0.56-0.92) for fruit juice, and 0.74 (95% Cl = 0.58-0.96) for green vegetables. This study provides additional evidence that high total fruit intake and certain fruit and vegetable intakes may be associated with a reduced risk of colorectal adenomas.

Original languageEnglish
Pages (from-to)340-344
Number of pages5
JournalJournal of Nutrition
Issue number2
Publication statusPublished - 2009 Feb

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


Dive into the research topics of 'Fruit and vegetable intakes are associated with lower risk of colorectal adenomas'. Together they form a unique fingerprint.

Cite this