Functional dilatation and medial remodeling of the renal artery in response to chronic increased blood flow

Jun-Neng Roan, Chin Yi Yeh, Wen Cheng Chiu, Chou Hwei Lee, Shih Wei Chang, Ya Fen Jiangshieh, Yu-Chuan Tsai, Chen Fuh Lam

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aims: Renal blood flow (RBF) is tightly regulated by several intrinsic pathways in maintaining optimal kidney blood supply. Using a rat model of aortocaval (AC) fistula, we investigated remodeling of the renal artery following prolonged increased blood flow. Methods: An AC fistula was created in the infrarenal aorta of anesthetized rats, and changes of blood flow in the renal artery were assessed using an ultrasonic flow probe. Morphological changes and expression of endothelial nitric oxide synthase and matrix metalloproteinase-2 in the remodeled renal artery were analyzed. Results: Blood flow in the renal artery increased immediately after creation of AC fistula, but normal RBF was restored 8 weeks later. The renal artery dilated significantly 8 weeks after operation. Expression of endothelial nitric oxide synthase and matrix metalloproteinase-2 was upregulated shortly after blood flow increase, and returned to baseline levels after 3 weeks. Histological sections showed luminal dilatation with medial thickening and endothelial cell-to-smooth muscle cell attachments in the remodeled renal artery. Conclusion: Increased RBF was accommodated by functional dilatation and remodeling in the medial layer of the renal artery in order to restore normal blood flow. Our results provide important mechanistic insight into the intrinsic regulation of the renal artery in response to increased RBF.

Original languageEnglish
Pages (from-to)447-456
Number of pages10
JournalKidney and Blood Pressure Research
Volume34
Issue number6
DOIs
Publication statusPublished - 2011 Nov 1

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Functional dilatation and medial remodeling of the renal artery in response to chronic increased blood flow'. Together they form a unique fingerprint.

  • Cite this

    Roan, J-N., Yeh, C. Y., Chiu, W. C., Lee, C. H., Chang, S. W., Jiangshieh, Y. F., Tsai, Y-C., & Lam, C. F. (2011). Functional dilatation and medial remodeling of the renal artery in response to chronic increased blood flow. Kidney and Blood Pressure Research, 34(6), 447-456. https://doi.org/10.1159/000329096