Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration.

Yun-Wen Chen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Vascularization of engineered tissues remains one of the key problems. Here, we described a novel approach to promote vascularization of engineered tissues using fibronectin (FN) incorporated gold nanoparticles (AuNP) coated onto catheters with mesenchymal stem cells (MSCs) for tissue engineering. We found that the FN-AuNP composite with 43.5 ppm of AuNP exhibited better biomechanical properties and thermal stability than pure FN. FN-AuNP composites promoted MSC proliferation and increased the biocompatibility. Mechanistically, vascular endothelial growth factor (VEGF) promoted MSC migration on FN-AuNP through the endothelial oxide synthase (eNOS)/metalloproteinase (MMP) signaling pathway. Vascular femoral artery tissues isolated from the implanted FN-AuNP-coated catheters with MSCs expressed substantial CD31 and alpha-smooth muscle actin (α-SMA), displayed higher antithrombotic activity, as well as better endothelialization ability than those coated with all other materials. These data suggested that the implantation of FN-AuNP-coated catheter with MSCs could be a novel strategy for vascular biomaterials applications.
Original languageEnglish
Pages (from-to)699-711
Number of pages13
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume14
Issue number3
Publication statusPublished - 2018 Apr
Externally publishedYes

Fingerprint Dive into the research topics of 'Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration.'. Together they form a unique fingerprint.

  • Cite this