Functional evaluation using multistep registration with standard magnetic resonance and ADAM brain images

Chung I. Huang, Yung Nien Sun, Wei Jen Yao

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: Image analysis of I ADAM single photon emission computed tomography is used to evaluate the functional activities in apparatus or in the brain regions. We have earlier proposed a two-step registration method for registering intrasubject long-time 2-[(2-((dimethyl-amino) methyl)phenyl)thio]- 5-iodophenylamine (ADAM) images. However, this method requires acquisition of individual MRI, 10-min ADAM, and 6-h ADAM images. METHODS: In this study, we propose using standard (std) brains to replace the individual MRI and 10-min ADAM images. We first use the MRIstd instead of the individual MRI. We then use the 10-min ADAMstd to replace the individual 10-min ADAM image. RESULTS: The results produced using the MRIstd method are close to the original two-step registration method (specific/nonspecific binding ratio, 4.211 vs. 4.326, P=0.055); and the 10 min ADAMstd method is close to the MRIstd method (specific/nonspecific binding ratio, 4.095 vs. 4.211, P=0.070). CONCLUSION: The proposed 10-min ADAMstd method yields acceptable quantitative measurements and significantly reduces patient loading by eliminating the additional individual MRI and 10-min ADAM imaging. More important, the interobserver problem can be solved because the area of interest (AOI) is drawn on the MRIstd once; the AOI drawn on the MRIstd can be mapped onto the registered 10-min ADAMstd, and the individual 6 h ADAM image can then be automatically evaluated with the AOI on the 10-min ADAMstd after the proposed registration. Thus, the examination of I ADAM thus becomes less expensive, more convenient, and useful for clinical applications.

Original languageEnglish
Pages (from-to)635-640
Number of pages6
JournalNuclear Medicine Communications
Issue number7
Publication statusPublished - 2011 Jul

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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