Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Jiwan Ge, Soumya G. Remesh, Michal Hammel, Si Pan, Andrew D. Mahan, Shuying Wang, Xinquan Wang

Research output: Contribution to journalArticle

Abstract

The IL-1 receptors are responsible for transmitting signaling in immune responses. Ge et al. investigated the effect of a common D2/D3 linker within IL-1 receptors and revealed the functional role of inherent inter-domain flexibility in ligand recognition and signal transduction.

Original languageEnglish
Pages (from-to)1296-1307.e5
JournalStructure
Volume27
Issue number8
DOIs
Publication statusPublished - 2019 Aug 6

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All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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