Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Jiwan Ge; Soumya G. Remesh; Michal Hammel; Si Pan; Andrew D. Mahan; Shuying Wang; Xinquan Wang

doi:10.1016/j.str.2019.05.011

Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Jiwan Ge, Soumya G. Remesh, Michal Hammel, Si Pan, Andrew D. Mahan, Shuying Wang, Xinquan Wang

Department of Microbiology and Immunology

Research output: Contribution to journal › Article

Abstract

The IL-1 receptors are responsible for transmitting signaling in immune responses. Ge et al. investigated the effect of a common D2/D3 linker within IL-1 receptors and revealed the functional role of inherent inter-domain flexibility in ligand recognition and signal transduction.

Original language	English
Pages (from-to)	1296-1307.e5
Journal	Structure
Volume	27
Issue number	8
DOIs	https://doi.org/10.1016/j.str.2019.05.011
Publication status	Published - 2019 Aug 6

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All Science Journal Classification (ASJC) codes

Structural Biology
Molecular Biology

Cite this

Ge, J., Remesh, S. G., Hammel, M., Pan, S., Mahan, A. D., Wang, S., & Wang, X. (2019). Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure, 27(8), 1296-1307.e5. https://doi.org/10.1016/j.str.2019.05.011

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Access to Document

10.1016/j.str.2019.05.011