Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Jiwan Ge, Soumya G. Remesh, Michal Hammel, Si Pan, Andrew D. Mahan, Shu-Ying Wang, Xinquan Wang

Research output: Contribution to journal › Article

Abstract

The IL-1 receptors are responsible for transmitting signaling in immune responses. Ge et al. investigated the effect of a common D2/D3 linker within IL-1 receptors and revealed the functional role of inherent inter-domain flexibility in ligand recognition and signal transduction.

Original languageEnglish
Pages (from-to)1296-1307.e5
JournalStructure
Volume27
Issue number8
DOIs
Publication statusPublished - 2019 Aug 6

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Interleukin-1 Receptors
Cytokines
Signal Transduction
Ligands

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

Cite this

Ge, Jiwan ; Remesh, Soumya G. ; Hammel, Michal ; Pan, Si ; Mahan, Andrew D. ; Wang, Shu-Ying ; Wang, Xinquan. / Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. In: Structure. 2019 ; Vol. 27, No. 8. pp. 1296-1307.e5.
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author = "Jiwan Ge and Remesh, {Soumya G.} and Michal Hammel and Si Pan and Mahan, {Andrew D.} and Shu-Ying Wang and Xinquan Wang",
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Ge, J, Remesh, SG, Hammel, M, Pan, S, Mahan, AD, Wang, S-Y & Wang, X 2019, 'Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling', Structure, vol. 27, no. 8, pp. 1296-1307.e5. https://doi.org/10.1016/j.str.2019.05.011

Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. / Ge, Jiwan; Remesh, Soumya G.; Hammel, Michal; Pan, Si; Mahan, Andrew D.; Wang, Shu-Ying; Wang, Xinquan.

In: Structure, Vol. 27, No. 8, 06.08.2019, p. 1296-1307.e5.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

AU - Ge, Jiwan

AU - Remesh, Soumya G.

AU - Hammel, Michal

AU - Pan, Si

AU - Mahan, Andrew D.

AU - Wang, Shu-Ying

AU - Wang, Xinquan

PY - 2019/8/6

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AB - The IL-1 receptors are responsible for transmitting signaling in immune responses. Ge et al. investigated the effect of a common D2/D3 linker within IL-1 receptors and revealed the functional role of inherent inter-domain flexibility in ligand recognition and signal transduction.

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Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S-Y et al. Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure. 2019 Aug 6;27(8):1296-1307.e5. https://doi.org/10.1016/j.str.2019.05.011

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