Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Jiwan Ge, Soumya G. Remesh, Michal Hammel, Si Pan, Andrew D. Mahan, Shu-Ying Wang, Xinquan Wang

Research output: Contribution to journalArticle

Abstract

The IL-1 receptors are responsible for transmitting signaling in immune responses. Ge et al. investigated the effect of a common D2/D3 linker within IL-1 receptors and revealed the functional role of inherent inter-domain flexibility in ligand recognition and signal transduction.

Original languageEnglish
Pages (from-to)1296-1307.e5
JournalStructure
Volume27
Issue number8
DOIs
Publication statusPublished - 2019 Aug 6

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Interleukin-1 Receptors
Cytokines
Signal Transduction
Ligands

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

Cite this

Ge, Jiwan ; Remesh, Soumya G. ; Hammel, Michal ; Pan, Si ; Mahan, Andrew D. ; Wang, Shu-Ying ; Wang, Xinquan. / Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. In: Structure. 2019 ; Vol. 27, No. 8. pp. 1296-1307.e5.
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Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. / Ge, Jiwan; Remesh, Soumya G.; Hammel, Michal; Pan, Si; Mahan, Andrew D.; Wang, Shu-Ying; Wang, Xinquan.

In: Structure, Vol. 27, No. 8, 06.08.2019, p. 1296-1307.e5.

Research output: Contribution to journalArticle

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AU - Wang, Shu-Ying

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