Functional Role of Mitochondrial DNA in Cancer Progression

Yang Hsiang Lin; Siew Na Lim; Cheng Yi Chen; Hsiang Cheng Chi; Chau Ting Yeh; Wey Ran Lin

doi:10.3390/ijms23031659

Functional Role of Mitochondrial DNA in Cancer Progression

Yang Hsiang Lin, Siew Na Lim, Cheng Yi Chen, Hsiang Cheng Chi, Chau Ting Yeh, Wey Ran Lin

Department of Cell Biology and Anatomy

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metab-olism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysreg-ulation of mitochondria-encoded genes are associated with survival outcomes among cancer pa-tients. On the other hand, nuclear-encoded genes have been found to regulate mitochon-dria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.

Original language	English
Article number	1659
Journal	International journal of molecular sciences
Volume	23
Issue number	3
DOIs	https://doi.org/10.3390/ijms23031659
Publication status	Published - 2022 Feb 1

All Science Journal Classification (ASJC) codes

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms23031659

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title = "Functional Role of Mitochondrial DNA in Cancer Progression",

abstract = "Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metab-olism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysreg-ulation of mitochondria-encoded genes are associated with survival outcomes among cancer pa-tients. On the other hand, nuclear-encoded genes have been found to regulate mitochon-dria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.",

author = "Lin, {Yang Hsiang} and Lim, {Siew Na} and Chen, {Cheng Yi} and Chi, {Hsiang Cheng} and Yeh, {Chau Ting} and Lin, {Wey Ran}",

note = "Funding Information: This work was supported by grants from Chang Gung Memorial Hospital, Taiwan (CMRPG3K2292, CMRPG3J0693 and CMRPG3J1681 to W.-R.L. and CMRPG3L1211 and NRRPG3L6011 to Y.-H.L.) and from the Ministry of Science and Technology of the Republic of China (MOST 109-2314-B-182A-068-and MOST 110-2314-B-182A-095-to W.-R.L and MOST 110-2311-B-182A-001-MY3 to Y.-H.L.). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

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doi = "10.3390/ijms23031659",

language = "English",

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TY - JOUR

T1 - Functional Role of Mitochondrial DNA in Cancer Progression

AU - Lin, Yang Hsiang

AU - Lim, Siew Na

AU - Chen, Cheng Yi

AU - Chi, Hsiang Cheng

AU - Yeh, Chau Ting

AU - Lin, Wey Ran

N1 - Funding Information: This work was supported by grants from Chang Gung Memorial Hospital, Taiwan (CMRPG3K2292, CMRPG3J0693 and CMRPG3J1681 to W.-R.L. and CMRPG3L1211 and NRRPG3L6011 to Y.-H.L.) and from the Ministry of Science and Technology of the Republic of China (MOST 109-2314-B-182A-068-and MOST 110-2314-B-182A-095-to W.-R.L and MOST 110-2311-B-182A-001-MY3 to Y.-H.L.). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metab-olism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysreg-ulation of mitochondria-encoded genes are associated with survival outcomes among cancer pa-tients. On the other hand, nuclear-encoded genes have been found to regulate mitochon-dria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.

AB - Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metab-olism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysreg-ulation of mitochondria-encoded genes are associated with survival outcomes among cancer pa-tients. On the other hand, nuclear-encoded genes have been found to regulate mitochon-dria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.

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Functional Role of Mitochondrial DNA in Cancer Progression

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