Functional Role of Mitochondrial DNA in Cancer Progression

Yang Hsiang Lin, Siew Na Lim, Cheng Yi Chen, Hsiang Cheng Chi, Chau Ting Yeh, Wey Ran Lin

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metab-olism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysreg-ulation of mitochondria-encoded genes are associated with survival outcomes among cancer pa-tients. On the other hand, nuclear-encoded genes have been found to regulate mitochon-dria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.

Original languageEnglish
Article number1659
JournalInternational journal of molecular sciences
Issue number3
Publication statusPublished - 2022 Feb 1

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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