Functions of DDR1 in epithelial cell differentiation

Yi Chun Yeh; Ming Jer Tang

doi:10.1007/978-1-4939-6383-6_13

Functions of DDR1 in epithelial cell differentiation

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Epithelial cell differentiation is a critical element in the development and progression of disease, and the assembly of adherens junctions is the limiting step that determines epithelial cell differentiation. Signals from the microenvironment, including growth factors, cytokines, or the extracellular matrix, all have a significant impact on the assembly of adherens junctions. An increase of collagen deposition is no longer considered to be a consequence, but rather an inducer of disease progression, as the signal from integrin a2β1 mediates epithelial dedifferentiation via disturbing the stability of adherens junctions. However, as a collagen receptor, discoidin domain receptor 1 (DDR1) exhibits counter effects in regulating epithelial cell differentiation. This is due to the ability of DDR1 to maintain the stability of adherens junctions. The evidence and mechanisms whereby DDR1 regulates epithelial cell differentiation will all be addressed in this chapter.

Original language	English
Title of host publication	Discoidin Domain Receptors in Health and Disease
Publisher	Springer New York
Pages	239-258
Number of pages	20
ISBN (Electronic)	9781493963836
ISBN (Print)	9781493963812
DOIs	https://doi.org/10.1007/978-1-4939-6383-6_13
Publication status	Published - 2016 Jan 1

All Science Journal Classification (ASJC) codes

General Medicine
General Immunology and Microbiology
General Biochemistry,Genetics and Molecular Biology

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10.1007/978-1-4939-6383-6_13

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Functions of DDR1 in epithelial cell differentiation

Abstract

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