Functions of DDR1 in epithelial cell differentiation

Yi Chun Yeh, Ming-Jer Tang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epithelial cell differentiation is a critical element in the development and progression of disease, and the assembly of adherens junctions is the limiting step that determines epithelial cell differentiation. Signals from the microenvironment, including growth factors, cytokines, or the extracellular matrix, all have a significant impact on the assembly of adherens junctions. An increase of collagen deposition is no longer considered to be a consequence, but rather an inducer of disease progression, as the signal from integrin a2β1 mediates epithelial dedifferentiation via disturbing the stability of adherens junctions. However, as a collagen receptor, discoidin domain receptor 1 (DDR1) exhibits counter effects in regulating epithelial cell differentiation. This is due to the ability of DDR1 to maintain the stability of adherens junctions. The evidence and mechanisms whereby DDR1 regulates epithelial cell differentiation will all be addressed in this chapter.

Original languageEnglish
Title of host publicationDiscoidin Domain Receptors in Health and Disease
PublisherSpringer New York
Pages239-258
Number of pages20
ISBN (Electronic)9781493963836
ISBN (Print)9781493963812
DOIs
Publication statusPublished - 2016 Jan 1

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Adherens Junctions
Cell Differentiation
Epithelial Cells
Disease Progression
Collagen Receptors
Integrins
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Collagen
Cytokines
Discoidin Domain Receptor 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Yeh, Y. C., & Tang, M-J. (2016). Functions of DDR1 in epithelial cell differentiation. In Discoidin Domain Receptors in Health and Disease (pp. 239-258). Springer New York. https://doi.org/10.1007/978-1-4939-6383-6_13
Yeh, Yi Chun ; Tang, Ming-Jer. / Functions of DDR1 in epithelial cell differentiation. Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. pp. 239-258
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Yeh, YC & Tang, M-J 2016, Functions of DDR1 in epithelial cell differentiation. in Discoidin Domain Receptors in Health and Disease. Springer New York, pp. 239-258. https://doi.org/10.1007/978-1-4939-6383-6_13

Functions of DDR1 in epithelial cell differentiation. / Yeh, Yi Chun; Tang, Ming-Jer.

Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. p. 239-258.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Yeh YC, Tang M-J. Functions of DDR1 in epithelial cell differentiation. In Discoidin Domain Receptors in Health and Disease. Springer New York. 2016. p. 239-258 https://doi.org/10.1007/978-1-4939-6383-6_13