Abstract
Epithelial cell differentiation is a critical element in the development and progression of disease, and the assembly of adherens junctions is the limiting step that determines epithelial cell differentiation. Signals from the microenvironment, including growth factors, cytokines, or the extracellular matrix, all have a significant impact on the assembly of adherens junctions. An increase of collagen deposition is no longer considered to be a consequence, but rather an inducer of disease progression, as the signal from integrin a2β1 mediates epithelial dedifferentiation via disturbing the stability of adherens junctions. However, as a collagen receptor, discoidin domain receptor 1 (DDR1) exhibits counter effects in regulating epithelial cell differentiation. This is due to the ability of DDR1 to maintain the stability of adherens junctions. The evidence and mechanisms whereby DDR1 regulates epithelial cell differentiation will all be addressed in this chapter.
| Original language | English |
|---|---|
| Title of host publication | Discoidin Domain Receptors in Health and Disease |
| Publisher | Springer New York |
| Pages | 239-258 |
| Number of pages | 20 |
| ISBN (Electronic) | 9781493963836 |
| ISBN (Print) | 9781493963812 |
| DOIs | |
| Publication status | Published - 2016 Jan 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Medicine(all)
- Immunology and Microbiology(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
}
Functions of DDR1 in epithelial cell differentiation. / Yeh, Yi Chun; Tang, Ming-Jer.
Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. p. 239-258.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Functions of DDR1 in epithelial cell differentiation
AU - Yeh, Yi Chun
AU - Tang, Ming-Jer
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Epithelial cell differentiation is a critical element in the development and progression of disease, and the assembly of adherens junctions is the limiting step that determines epithelial cell differentiation. Signals from the microenvironment, including growth factors, cytokines, or the extracellular matrix, all have a significant impact on the assembly of adherens junctions. An increase of collagen deposition is no longer considered to be a consequence, but rather an inducer of disease progression, as the signal from integrin a2β1 mediates epithelial dedifferentiation via disturbing the stability of adherens junctions. However, as a collagen receptor, discoidin domain receptor 1 (DDR1) exhibits counter effects in regulating epithelial cell differentiation. This is due to the ability of DDR1 to maintain the stability of adherens junctions. The evidence and mechanisms whereby DDR1 regulates epithelial cell differentiation will all be addressed in this chapter.
AB - Epithelial cell differentiation is a critical element in the development and progression of disease, and the assembly of adherens junctions is the limiting step that determines epithelial cell differentiation. Signals from the microenvironment, including growth factors, cytokines, or the extracellular matrix, all have a significant impact on the assembly of adherens junctions. An increase of collagen deposition is no longer considered to be a consequence, but rather an inducer of disease progression, as the signal from integrin a2β1 mediates epithelial dedifferentiation via disturbing the stability of adherens junctions. However, as a collagen receptor, discoidin domain receptor 1 (DDR1) exhibits counter effects in regulating epithelial cell differentiation. This is due to the ability of DDR1 to maintain the stability of adherens junctions. The evidence and mechanisms whereby DDR1 regulates epithelial cell differentiation will all be addressed in this chapter.
UR - http://www.scopus.com/inward/record.url?scp=85016724537&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016724537&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-6383-6_13
DO - 10.1007/978-1-4939-6383-6_13
M3 - Chapter
AN - SCOPUS:85016724537
SN - 9781493963812
SP - 239
EP - 258
BT - Discoidin Domain Receptors in Health and Disease
PB - Springer New York
ER -