Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus

Jiun-Ling Wang, Hung Jen Tang, Pang Hsin Hsieh, Fang Yao Chiu, Yen Hsu Chen, Ming Chau Chang, Ching Tai Huang, Chang Pan Liu, Yeu Jun Lau, Kao Pin Hwang, Wen-Chien Ko, Chen Ti Wang, Cheng Yi Liu, Chien Lin Liu, Po Ren Hsueh

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Abstract

There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment of bone and joint infections (BJIs). The in vitro activity of FA against meticillin-resistant Staphylococcus aureus (MRSA) isolates remains good, with low (<10%) resistance rates in most Asian countries. FA in Asia appears to be a better oral anti-MRSA agent than trimethoprim/sulfamethoxazole and clindamycin. More than 80 cases of FA use for BJI have been reported since 2000 and the recurrence or failure rate is <10%. There is much evidence supporting the use of FA in combination with other antibiotics (e.g. rifampicin) as an oral treatment following intravenous glycopeptide treatment for BJIs.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalInternational journal of antimicrobial agents
Volume40
Issue number2
DOIs
Publication statusPublished - 2012 Jan 1

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All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Wang, J-L., Tang, H. J., Hsieh, P. H., Chiu, F. Y., Chen, Y. H., Chang, M. C., Huang, C. T., Liu, C. P., Lau, Y. J., Hwang, K. P., Ko, W-C., Wang, C. T., Liu, C. Y., Liu, C. L., & Hsueh, P. R. (2012). Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus. International journal of antimicrobial agents, 40(2), 103-107. https://doi.org/10.1016/j.ijantimicag.2012.03.010