Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus

Jiun-Ling Wang, Hung Jen Tang, Pang Hsin Hsieh, Fang Yao Chiu, Yen Hsu Chen, Ming Chau Chang, Ching Tai Huang, Chang Pan Liu, Yeu Jun Lau, Kao Pin Hwang, Wen-Chien Ko, Chen Ti Wang, Cheng Yi Liu, Chien Lin Liu, Po Ren Hsueh

Research output: Contribution to journalShort survey

21 Citations (Scopus)

Abstract

There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment of bone and joint infections (BJIs). The in vitro activity of FA against meticillin-resistant Staphylococcus aureus (MRSA) isolates remains good, with low (<10%) resistance rates in most Asian countries. FA in Asia appears to be a better oral anti-MRSA agent than trimethoprim/sulfamethoxazole and clindamycin. More than 80 cases of FA use for BJI have been reported since 2000 and the recurrence or failure rate is <10%. There is much evidence supporting the use of FA in combination with other antibiotics (e.g. rifampicin) as an oral treatment following intravenous glycopeptide treatment for BJIs.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalInternational journal of antimicrobial agents
Volume40
Issue number2
DOIs
Publication statusPublished - 2012 Jan 1

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Fusidic Acid
Methicillin
Staphylococcus aureus
Joints
Bone and Bones
Infection
Clindamycin
Glycopeptides
Sulfamethoxazole Drug Combination Trimethoprim
Rifampin
Orthopedics
Anti-Bacterial Agents
Recurrence

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Wang, Jiun-Ling ; Tang, Hung Jen ; Hsieh, Pang Hsin ; Chiu, Fang Yao ; Chen, Yen Hsu ; Chang, Ming Chau ; Huang, Ching Tai ; Liu, Chang Pan ; Lau, Yeu Jun ; Hwang, Kao Pin ; Ko, Wen-Chien ; Wang, Chen Ti ; Liu, Cheng Yi ; Liu, Chien Lin ; Hsueh, Po Ren. / Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus. In: International journal of antimicrobial agents. 2012 ; Vol. 40, No. 2. pp. 103-107.
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author = "Jiun-Ling Wang and Tang, {Hung Jen} and Hsieh, {Pang Hsin} and Chiu, {Fang Yao} and Chen, {Yen Hsu} and Chang, {Ming Chau} and Huang, {Ching Tai} and Liu, {Chang Pan} and Lau, {Yeu Jun} and Hwang, {Kao Pin} and Wen-Chien Ko and Wang, {Chen Ti} and Liu, {Cheng Yi} and Liu, {Chien Lin} and Hsueh, {Po Ren}",
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Wang, J-L, Tang, HJ, Hsieh, PH, Chiu, FY, Chen, YH, Chang, MC, Huang, CT, Liu, CP, Lau, YJ, Hwang, KP, Ko, W-C, Wang, CT, Liu, CY, Liu, CL & Hsueh, PR 2012, 'Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus', International journal of antimicrobial agents, vol. 40, no. 2, pp. 103-107. https://doi.org/10.1016/j.ijantimicag.2012.03.010

Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus. / Wang, Jiun-Ling; Tang, Hung Jen; Hsieh, Pang Hsin; Chiu, Fang Yao; Chen, Yen Hsu; Chang, Ming Chau; Huang, Ching Tai; Liu, Chang Pan; Lau, Yeu Jun; Hwang, Kao Pin; Ko, Wen-Chien; Wang, Chen Ti; Liu, Cheng Yi; Liu, Chien Lin; Hsueh, Po Ren.

In: International journal of antimicrobial agents, Vol. 40, No. 2, 01.01.2012, p. 103-107.

Research output: Contribution to journalShort survey

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AU - Wang, Jiun-Ling

AU - Tang, Hung Jen

AU - Hsieh, Pang Hsin

AU - Chiu, Fang Yao

AU - Chen, Yen Hsu

AU - Chang, Ming Chau

AU - Huang, Ching Tai

AU - Liu, Chang Pan

AU - Lau, Yeu Jun

AU - Hwang, Kao Pin

AU - Ko, Wen-Chien

AU - Wang, Chen Ti

AU - Liu, Cheng Yi

AU - Liu, Chien Lin

AU - Hsueh, Po Ren

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Y1 - 2012/1/1

N2 - There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment of bone and joint infections (BJIs). The in vitro activity of FA against meticillin-resistant Staphylococcus aureus (MRSA) isolates remains good, with low (<10%) resistance rates in most Asian countries. FA in Asia appears to be a better oral anti-MRSA agent than trimethoprim/sulfamethoxazole and clindamycin. More than 80 cases of FA use for BJI have been reported since 2000 and the recurrence or failure rate is <10%. There is much evidence supporting the use of FA in combination with other antibiotics (e.g. rifampicin) as an oral treatment following intravenous glycopeptide treatment for BJIs.

AB - There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment of bone and joint infections (BJIs). The in vitro activity of FA against meticillin-resistant Staphylococcus aureus (MRSA) isolates remains good, with low (<10%) resistance rates in most Asian countries. FA in Asia appears to be a better oral anti-MRSA agent than trimethoprim/sulfamethoxazole and clindamycin. More than 80 cases of FA use for BJI have been reported since 2000 and the recurrence or failure rate is <10%. There is much evidence supporting the use of FA in combination with other antibiotics (e.g. rifampicin) as an oral treatment following intravenous glycopeptide treatment for BJIs.

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