Gallstone disease associated with increased risk of arterial stiffness in a Taiwanese population

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Abstract

Arterial stiffness has similar risk factors to gallstone disease (GSD). However, there are few studies on the association between arterial stiffness and GSD. The aim of this study was to determine the relationship between arterial stiffness and GSD in a Taiwanese population. We enroled 6211 subjects from a health examination centre after excluding those who received medications for diabetes, hypertension and hyperlipidemia or had a history of cardiovascular disease, cerebrovascular disease, cancer, cholecystectomy or ankle-brachial index of ≤ 0.9 or≥1.3. Increased arterial stiffness was defined as right brachial-ankle pulse wave velocity (baPWV) ≥1400 cm s -1. The diagnosis of GSD was based on ultrasonographic findings. The prevalence of increased arterial stiffness was 47.2 and 31.9 % in subjects with and without GSD (P<0.001). A multiple linear regression analysis revealed that GSD, age, systolic blood pressure, fasting plasma glucose and current smoking were positively associated with baPWV, whereas male gender, BMI, habitual exercise and HDL-C were negatively related to baPWV after adjusting for other clinical variables. In conclusion, subjects with GSD are associated with an increased risk of arterial stiffness.

Original languageEnglish
Pages (from-to)616-619
Number of pages4
JournalJournal of Human Hypertension
Volume31
Issue number10
DOIs
Publication statusPublished - 2017 Oct 1

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Vascular Stiffness
Gallstones
Pulse Wave Analysis
Population
Ankle
Arm
Blood Pressure
Cerebrovascular Disorders
Ankle Brachial Index
Cholecystectomy
Hyperlipidemias
Linear Models
Fasting
Cardiovascular Diseases
Smoking
Regression Analysis
Hypertension
Glucose
Health

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

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title = "Gallstone disease associated with increased risk of arterial stiffness in a Taiwanese population",
abstract = "Arterial stiffness has similar risk factors to gallstone disease (GSD). However, there are few studies on the association between arterial stiffness and GSD. The aim of this study was to determine the relationship between arterial stiffness and GSD in a Taiwanese population. We enroled 6211 subjects from a health examination centre after excluding those who received medications for diabetes, hypertension and hyperlipidemia or had a history of cardiovascular disease, cerebrovascular disease, cancer, cholecystectomy or ankle-brachial index of ≤ 0.9 or≥1.3. Increased arterial stiffness was defined as right brachial-ankle pulse wave velocity (baPWV) ≥1400 cm s -1. The diagnosis of GSD was based on ultrasonographic findings. The prevalence of increased arterial stiffness was 47.2 and 31.9 {\%} in subjects with and without GSD (P<0.001). A multiple linear regression analysis revealed that GSD, age, systolic blood pressure, fasting plasma glucose and current smoking were positively associated with baPWV, whereas male gender, BMI, habitual exercise and HDL-C were negatively related to baPWV after adjusting for other clinical variables. In conclusion, subjects with GSD are associated with an increased risk of arterial stiffness.",
author = "Wang, {J. Y.} and Feng-Hwa Lu and Zih-Jie Sun and Jin-Shang Wu and Yi-Ching Yang and Chih-Ting Lee and Chih-Jen Chang",
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AU - Lu, Feng-Hwa

AU - Sun, Zih-Jie

AU - Wu, Jin-Shang

AU - Yang, Yi-Ching

AU - Lee, Chih-Ting

AU - Chang, Chih-Jen

PY - 2017/10/1

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