Abstract
Arterial stiffness has similar risk factors to gallstone disease (GSD). However, there are few studies on the association between arterial stiffness and GSD. The aim of this study was to determine the relationship between arterial stiffness and GSD in a Taiwanese population. We enroled 6211 subjects from a health examination centre after excluding those who received medications for diabetes, hypertension and hyperlipidemia or had a history of cardiovascular disease, cerebrovascular disease, cancer, cholecystectomy or ankle-brachial index of ≤ 0.9 or≥1.3. Increased arterial stiffness was defined as right brachial-ankle pulse wave velocity (baPWV) ≥1400 cm s -1. The diagnosis of GSD was based on ultrasonographic findings. The prevalence of increased arterial stiffness was 47.2 and 31.9 % in subjects with and without GSD (P<0.001). A multiple linear regression analysis revealed that GSD, age, systolic blood pressure, fasting plasma glucose and current smoking were positively associated with baPWV, whereas male gender, BMI, habitual exercise and HDL-C were negatively related to baPWV after adjusting for other clinical variables. In conclusion, subjects with GSD are associated with an increased risk of arterial stiffness.
| Original language | English |
|---|---|
| Pages (from-to) | 616-619 |
| Number of pages | 4 |
| Journal | Journal of Human Hypertension |
| Volume | 31 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2017 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
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Gallstone disease associated with increased risk of arterial stiffness in a Taiwanese population. / Wang, J. Y.; Lu, Feng-Hwa; Sun, Zih-Jie; Wu, Jin-Shang; Yang, Yi-Ching; Lee, Chih-Ting; Chang, Chih-Jen.
In: Journal of Human Hypertension, Vol. 31, No. 10, 01.10.2017, p. 616-619.Research output: Contribution to journal › Article
TY - JOUR
T1 - Gallstone disease associated with increased risk of arterial stiffness in a Taiwanese population
AU - Wang, J. Y.
AU - Lu, Feng-Hwa
AU - Sun, Zih-Jie
AU - Wu, Jin-Shang
AU - Yang, Yi-Ching
AU - Lee, Chih-Ting
AU - Chang, Chih-Jen
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Arterial stiffness has similar risk factors to gallstone disease (GSD). However, there are few studies on the association between arterial stiffness and GSD. The aim of this study was to determine the relationship between arterial stiffness and GSD in a Taiwanese population. We enroled 6211 subjects from a health examination centre after excluding those who received medications for diabetes, hypertension and hyperlipidemia or had a history of cardiovascular disease, cerebrovascular disease, cancer, cholecystectomy or ankle-brachial index of ≤ 0.9 or≥1.3. Increased arterial stiffness was defined as right brachial-ankle pulse wave velocity (baPWV) ≥1400 cm s -1. The diagnosis of GSD was based on ultrasonographic findings. The prevalence of increased arterial stiffness was 47.2 and 31.9 % in subjects with and without GSD (P<0.001). A multiple linear regression analysis revealed that GSD, age, systolic blood pressure, fasting plasma glucose and current smoking were positively associated with baPWV, whereas male gender, BMI, habitual exercise and HDL-C were negatively related to baPWV after adjusting for other clinical variables. In conclusion, subjects with GSD are associated with an increased risk of arterial stiffness.
AB - Arterial stiffness has similar risk factors to gallstone disease (GSD). However, there are few studies on the association between arterial stiffness and GSD. The aim of this study was to determine the relationship between arterial stiffness and GSD in a Taiwanese population. We enroled 6211 subjects from a health examination centre after excluding those who received medications for diabetes, hypertension and hyperlipidemia or had a history of cardiovascular disease, cerebrovascular disease, cancer, cholecystectomy or ankle-brachial index of ≤ 0.9 or≥1.3. Increased arterial stiffness was defined as right brachial-ankle pulse wave velocity (baPWV) ≥1400 cm s -1. The diagnosis of GSD was based on ultrasonographic findings. The prevalence of increased arterial stiffness was 47.2 and 31.9 % in subjects with and without GSD (P<0.001). A multiple linear regression analysis revealed that GSD, age, systolic blood pressure, fasting plasma glucose and current smoking were positively associated with baPWV, whereas male gender, BMI, habitual exercise and HDL-C were negatively related to baPWV after adjusting for other clinical variables. In conclusion, subjects with GSD are associated with an increased risk of arterial stiffness.
UR - http://www.scopus.com/inward/record.url?scp=85029129175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029129175&partnerID=8YFLogxK
U2 - 10.1038/jhh.2017.43
DO - 10.1038/jhh.2017.43
M3 - Article
C2 - 28660886
AN - SCOPUS:85029129175
VL - 31
SP - 616
EP - 619
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
SN - 0950-9240
IS - 10
ER -