Gastroesophageal reflux disease and atrial fibrillation: Insight from autonomic cardiogastric neural interaction

Ting Chun Huang, Li Wei Lo, Shinya Yamada, Yu Hui Chou, Wei Lun Lin, Shih Lin Chang, Yenn Jiang Lin, Shin Huei Liu, Wen Han Cheng, Tsung Ying Tsai, Ping Yen Liu, Shih Ann Chen

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background: The relationship between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF) has been previously reported. However, the detailed mechanism remains unknown. In this study, we investigated the effects of acid reflux on the intrinsic cardiac autonomic nervous system, atrial/ventricular electrophysiology, and AF inducibility. Methods: Eighteen rabbits were randomized into three groups: acid reflux (group 1, n = 6), control (group 2, n = 6), and acid reflux with periesophageal vagal blockade (group 3, n = 6). Atrial and ventricular effective refractory periods (ERPs) and AF inducibility were checked at baseline and then hourly until 5 hours after the experiment. Results: Three hours after the experiment, atrial ERP prolongation was noted in groups 2 and 3 (P <.05), whereas shortening of the atrial ERPs was observed in group 1, compared with the baseline. However, no changes were observed in ventricular ERPs in the three groups. The AF inducibility was higher in group 1 than in groups 2 and 3. Pathological examination showed clear esophageal mucosal breaks in groups 1 and 3. Conclusions: In this study, we found that the antimuscarinic blockade prevents GERD induced changes to atrial electrophysiology and susceptibility to AF—making it highly likely that autonomic activity is important in mediating this effect.

Original languageEnglish
Pages (from-to)2262-2270
Number of pages9
JournalJournal of Cardiovascular Electrophysiology
Issue number11
Publication statusPublished - 2019 Nov 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Gastroesophageal reflux disease and atrial fibrillation: Insight from autonomic cardiogastric neural interaction'. Together they form a unique fingerprint.

Cite this