Gender difference in antidepressant-related sexual dysfunction in Taiwan

Tzu I. Lee, Joana Issac, Shih Hsien Lin, Tzung Lieh Yeh, I. Hui Lee, Po See Chen, Kao Chin Chen, Yen Kuang Yang

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Objective: Sexual dysfunction accompanied by depression may be altered by antidepressants. The effects of antidepressants on sexual dysfunction among males and females remain to be investigated. Methods: Three groups of subjects, drug-free patients with depression (N= 125), medicated patients with depression (N= 145) and healthy volunteers (N= 255), were recruited. A Chinese version of the Changes in Sexual Functioning Questionnaire was employed to assess sexual function as the primary outcome. Results: Drug-free depressed females and medicated depressed males had more sexual dysfunction than healthy controls. The desire for sexual behaviors among healthy females and medicated depressed females was higher than that of drug-free depressed females. Conclusion: Depression and antidepressants may have different impacts on the sexual function of males and females.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalGeneral Hospital Psychiatry
Issue number4
Publication statusPublished - 2013 Jul

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health


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