TY - JOUR
T1 - Gender difference of alanine aminotransferase elevation may be associated with higher hemoglobin levels among male adolescents
AU - Chen, Solomon Chih Cheng
AU - Yeh, Jun Jun
AU - Chang, Mei Hwei
AU - Liao, Yu Kuei
AU - Hsiao, Li Chen
AU - Neoh, Choo Aun
AU - Tok, Teck Siang
AU - Wang, Jung Der
N1 - Funding Information:
The health checkup for the surveyed students was sponsored by the Pingtung and Taitung county governments, and provided by the Health Checkup Team of the Department of Clinical Service of Pingtung Christian Hospital, Taiwan.
PY - 2010
Y1 - 2010
N2 - Background: To explore the gender difference of ALT elevation and its association with high hemoglobin levels. Methods: A cross-sectional study of 3547 adolescents (2005 females, mean age of 16.5?.3 years) who were negative for hepatitis B surface antigen received health checkups in 2006. Body mass index (BMI), levels of hemoglobin, ALT and cholesterol were measured. ALT >42 U/L was defined as elevated ALT. Elevated ALT levels were detected in 112 of the 3547 participants (3.3%), more prevalent in males than in females (5.4% vs. 1.4%, p<0.001). Hemoglobin levels had a significant linear correlation with ALT levels in both genders. Abnormal ALT started to occur if hemoglobin.11 g/dl in females or.13.5 g/dl in males, but the cumulative cases of elevated ALT increased more quickly in males. Proportion of elevated ALT increased as either the BMI or hemoglobin level rise, more apparent in male adolescents. Logistic regression modeling showed odds ratio (95% confidence interval) were 24.7 (15.0-40.6) for BMI ≥27 kg/m2; 5.5 (2.9-10.4) for BMI 24-27 kg/m2; 2.7 (1.3-5.5) for Q5 (top 20th percentile) hemoglobin level; and 2.6 (1.6-4.1) for male gender. Further separately fitting the logistic models for two genders, the significance of Q5 hemoglobin level only appeared in the males. Conclusions: High hemoglobin level is a significant risk factor of ALT elevation after control hepatitis B, obesity and gender. Males have greater risk of abnormal liver function which may be associated with higher hemoglobin levels.
AB - Background: To explore the gender difference of ALT elevation and its association with high hemoglobin levels. Methods: A cross-sectional study of 3547 adolescents (2005 females, mean age of 16.5?.3 years) who were negative for hepatitis B surface antigen received health checkups in 2006. Body mass index (BMI), levels of hemoglobin, ALT and cholesterol were measured. ALT >42 U/L was defined as elevated ALT. Elevated ALT levels were detected in 112 of the 3547 participants (3.3%), more prevalent in males than in females (5.4% vs. 1.4%, p<0.001). Hemoglobin levels had a significant linear correlation with ALT levels in both genders. Abnormal ALT started to occur if hemoglobin.11 g/dl in females or.13.5 g/dl in males, but the cumulative cases of elevated ALT increased more quickly in males. Proportion of elevated ALT increased as either the BMI or hemoglobin level rise, more apparent in male adolescents. Logistic regression modeling showed odds ratio (95% confidence interval) were 24.7 (15.0-40.6) for BMI ≥27 kg/m2; 5.5 (2.9-10.4) for BMI 24-27 kg/m2; 2.7 (1.3-5.5) for Q5 (top 20th percentile) hemoglobin level; and 2.6 (1.6-4.1) for male gender. Further separately fitting the logistic models for two genders, the significance of Q5 hemoglobin level only appeared in the males. Conclusions: High hemoglobin level is a significant risk factor of ALT elevation after control hepatitis B, obesity and gender. Males have greater risk of abnormal liver function which may be associated with higher hemoglobin levels.
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U2 - 10.1371/journal.pone.0013269
DO - 10.1371/journal.pone.0013269
M3 - Article
C2 - 20967274
AN - SCOPUS:78149463549
SN - 1932-6203
VL - 5
JO - PloS one
JF - PloS one
IS - 10
M1 - e13269
ER -