Gender difference of circulating ghrelin and leptin concentrations in Chronic Helicobacter pylori infection

Chiao-Hsiung Chuang, Bor-Shyang Sheu, Hsiao Bai Yang, Shui Cheng Lee, Ai Wen Kao, Hsiu-Chi Cheng, Wei-Lun Chang, Wei-Jen Yao

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Both ghrelin and leptin are important appetite hormones secreted from the stomach. We examined whether demographic background, Helicobacter pylori infection, or its related gastritis severity could be associated with circulating ghrelin and leptin levels. Methods: This study prospectively enrolled 341 dyspeptic patients (196 females, 145 males), who had received endoscopy to provide the gastric specimens over both antrum and corpus for histology reviewed by the updated Sydney's system. The fasting blood sample of each patient was obtained for total ghrelin and leptin analysis. Results: Without H. pylori infection, there were similar ghrelin levels between female and male patients. In the H. pylori-infected patients, the males had lower plasma ghrelin levels than females (1053 vs. 1419 pg/mL, p <.001). Only in males, not in females, the H. pylori infection and its related acute and chronic inflammation scores were significantly associated with a lower ghrelin level (p ≤.04). The multivariate regression disclosed that only the chronic inflammation score independently related to a lower ghrelin level. Only in males, the ghrelin levels ranked in a downward trend for the gastritis feature as with limited-gastritis, with antrum-predominant gastritis, and with corpus-gastritis (1236, 1101, and 977 pg/mL). Leptin level was not related to H. pylori-related gastritis, but positively related to body mass index. Conclusion: There should be a gender difference to circulating total ghrelin levels, but not leptin levels, in response to H. pylori infection and its related chronic gastritis.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalHelicobacter
Volume14
Issue number1
DOIs
Publication statusPublished - 2009 Feb 1

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Ghrelin
Helicobacter Infections
Leptin
Helicobacter pylori
Gastritis
Stomach
Inflammation
Appetite
Endoscopy
Fasting
Histology
Body Mass Index
Demography
Hormones

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Infectious Diseases

Cite this

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title = "Gender difference of circulating ghrelin and leptin concentrations in Chronic Helicobacter pylori infection",
abstract = "Background: Both ghrelin and leptin are important appetite hormones secreted from the stomach. We examined whether demographic background, Helicobacter pylori infection, or its related gastritis severity could be associated with circulating ghrelin and leptin levels. Methods: This study prospectively enrolled 341 dyspeptic patients (196 females, 145 males), who had received endoscopy to provide the gastric specimens over both antrum and corpus for histology reviewed by the updated Sydney's system. The fasting blood sample of each patient was obtained for total ghrelin and leptin analysis. Results: Without H. pylori infection, there were similar ghrelin levels between female and male patients. In the H. pylori-infected patients, the males had lower plasma ghrelin levels than females (1053 vs. 1419 pg/mL, p <.001). Only in males, not in females, the H. pylori infection and its related acute and chronic inflammation scores were significantly associated with a lower ghrelin level (p ≤.04). The multivariate regression disclosed that only the chronic inflammation score independently related to a lower ghrelin level. Only in males, the ghrelin levels ranked in a downward trend for the gastritis feature as with limited-gastritis, with antrum-predominant gastritis, and with corpus-gastritis (1236, 1101, and 977 pg/mL). Leptin level was not related to H. pylori-related gastritis, but positively related to body mass index. Conclusion: There should be a gender difference to circulating total ghrelin levels, but not leptin levels, in response to H. pylori infection and its related chronic gastritis.",
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Gender difference of circulating ghrelin and leptin concentrations in Chronic Helicobacter pylori infection. / Chuang, Chiao-Hsiung; Sheu, Bor-Shyang; Yang, Hsiao Bai; Lee, Shui Cheng; Kao, Ai Wen; Cheng, Hsiu-Chi; Chang, Wei-Lun; Yao, Wei-Jen.

In: Helicobacter, Vol. 14, No. 1, 01.02.2009, p. 54-60.

Research output: Contribution to journalArticle

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AU - Sheu, Bor-Shyang

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AU - Lee, Shui Cheng

AU - Kao, Ai Wen

AU - Cheng, Hsiu-Chi

AU - Chang, Wei-Lun

AU - Yao, Wei-Jen

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N2 - Background: Both ghrelin and leptin are important appetite hormones secreted from the stomach. We examined whether demographic background, Helicobacter pylori infection, or its related gastritis severity could be associated with circulating ghrelin and leptin levels. Methods: This study prospectively enrolled 341 dyspeptic patients (196 females, 145 males), who had received endoscopy to provide the gastric specimens over both antrum and corpus for histology reviewed by the updated Sydney's system. The fasting blood sample of each patient was obtained for total ghrelin and leptin analysis. Results: Without H. pylori infection, there were similar ghrelin levels between female and male patients. In the H. pylori-infected patients, the males had lower plasma ghrelin levels than females (1053 vs. 1419 pg/mL, p <.001). Only in males, not in females, the H. pylori infection and its related acute and chronic inflammation scores were significantly associated with a lower ghrelin level (p ≤.04). The multivariate regression disclosed that only the chronic inflammation score independently related to a lower ghrelin level. Only in males, the ghrelin levels ranked in a downward trend for the gastritis feature as with limited-gastritis, with antrum-predominant gastritis, and with corpus-gastritis (1236, 1101, and 977 pg/mL). Leptin level was not related to H. pylori-related gastritis, but positively related to body mass index. Conclusion: There should be a gender difference to circulating total ghrelin levels, but not leptin levels, in response to H. pylori infection and its related chronic gastritis.

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