Gender differences in the association of non-alcoholic fatty liver disease and metabolic syndrome with erosive oesophagitis: A cross-sectional study in a Taiwanese population

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Abstract

Objectives Although metabolic syndrome correlates with erosive oesophagitis, few studies have examined the association between non-alcoholic fatty liver disease (NAFLD), associated with obesity and insulin resistance as metabolic syndrome, and erosive oesophagitis. The possible gender differences in risk factors of erosive oesophagitis should be considered. This study aimed to determine the concomitant effects of NAFLD and metabolic syndrome on erosive oesophagitis with respect to gender. Design, setting, participants and outcome measures This cross-sectional study, conducted between January 2000 and August 2009, included 12090 participants from the health examination center of a tertiary hospital. NAFLD was diagnosed according to ultrasonographic findings after excluding participants with excessive alcohol consumption or other liver diseases. Metabolic syndrome was determined using the revised National Cholesterol Education Program Adult Treatment Panel III criteria. Erosive oesophagitis was defined according to the Los Angeles classification by oesophagogastroduodenoscopy. Results On the basis of the oesophagogastroduodenoscopic findings, the prevalence of erosive oesophagitis was 20.1% (n=1427/7110) and 9.9% (n=477/4842) in males and females, respectively. After adjusting for other variables, metabolic syndrome (OR 1.26; 95% CI 1.09 to 1.45) but not NAFLD (OR 1.14; 95% CI 0.98 to 1.30) significantly correlated with erosive oesophagitis in males, while NAFLD (OR 1.50; 95% CI 1.21 to 1.86) but not metabolic syndrome (OR 1.24; 95% CI 0.94 to 1.63) positively correlated with erosive oesophagitis in females. Conclusions The detrimental effect on erosive oesophagitis is greater by metabolic syndrome than by NAFLD in males but greater by NAFLD than by metabolic syndrome in females.

Original languageEnglish
Article numbere013106
JournalBMJ open
Volume6
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

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Esophagitis
Cross-Sectional Studies
Population
Digestive System Endoscopy
Non-alcoholic Fatty Liver Disease
Los Angeles
Tertiary Care Centers
Alcohol Drinking
Insulin Resistance
Liver Diseases
Obesity
Cholesterol
Outcome Assessment (Health Care)
Education
Health

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{6bffdb8c4b04432c8cced79adc82601a,
title = "Gender differences in the association of non-alcoholic fatty liver disease and metabolic syndrome with erosive oesophagitis: A cross-sectional study in a Taiwanese population",
abstract = "Objectives Although metabolic syndrome correlates with erosive oesophagitis, few studies have examined the association between non-alcoholic fatty liver disease (NAFLD), associated with obesity and insulin resistance as metabolic syndrome, and erosive oesophagitis. The possible gender differences in risk factors of erosive oesophagitis should be considered. This study aimed to determine the concomitant effects of NAFLD and metabolic syndrome on erosive oesophagitis with respect to gender. Design, setting, participants and outcome measures This cross-sectional study, conducted between January 2000 and August 2009, included 12090 participants from the health examination center of a tertiary hospital. NAFLD was diagnosed according to ultrasonographic findings after excluding participants with excessive alcohol consumption or other liver diseases. Metabolic syndrome was determined using the revised National Cholesterol Education Program Adult Treatment Panel III criteria. Erosive oesophagitis was defined according to the Los Angeles classification by oesophagogastroduodenoscopy. Results On the basis of the oesophagogastroduodenoscopic findings, the prevalence of erosive oesophagitis was 20.1{\%} (n=1427/7110) and 9.9{\%} (n=477/4842) in males and females, respectively. After adjusting for other variables, metabolic syndrome (OR 1.26; 95{\%} CI 1.09 to 1.45) but not NAFLD (OR 1.14; 95{\%} CI 0.98 to 1.30) significantly correlated with erosive oesophagitis in males, while NAFLD (OR 1.50; 95{\%} CI 1.21 to 1.86) but not metabolic syndrome (OR 1.24; 95{\%} CI 0.94 to 1.63) positively correlated with erosive oesophagitis in females. Conclusions The detrimental effect on erosive oesophagitis is greater by metabolic syndrome than by NAFLD in males but greater by NAFLD than by metabolic syndrome in females.",
author = "Hung, {Wei Chieh} and Wu, {Jin Shang} and Sun, {Zih Jie} and Lu, {Feng Hwa} and Yang, {Yi Ching} and Chang, {Chih Jen}",
year = "2016",
month = "11",
day = "1",
doi = "10.1136/bmjopen-2016-013106",
language = "English",
volume = "6",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "11",

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TY - JOUR

T1 - Gender differences in the association of non-alcoholic fatty liver disease and metabolic syndrome with erosive oesophagitis

T2 - A cross-sectional study in a Taiwanese population

AU - Hung, Wei Chieh

AU - Wu, Jin Shang

AU - Sun, Zih Jie

AU - Lu, Feng Hwa

AU - Yang, Yi Ching

AU - Chang, Chih Jen

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Objectives Although metabolic syndrome correlates with erosive oesophagitis, few studies have examined the association between non-alcoholic fatty liver disease (NAFLD), associated with obesity and insulin resistance as metabolic syndrome, and erosive oesophagitis. The possible gender differences in risk factors of erosive oesophagitis should be considered. This study aimed to determine the concomitant effects of NAFLD and metabolic syndrome on erosive oesophagitis with respect to gender. Design, setting, participants and outcome measures This cross-sectional study, conducted between January 2000 and August 2009, included 12090 participants from the health examination center of a tertiary hospital. NAFLD was diagnosed according to ultrasonographic findings after excluding participants with excessive alcohol consumption or other liver diseases. Metabolic syndrome was determined using the revised National Cholesterol Education Program Adult Treatment Panel III criteria. Erosive oesophagitis was defined according to the Los Angeles classification by oesophagogastroduodenoscopy. Results On the basis of the oesophagogastroduodenoscopic findings, the prevalence of erosive oesophagitis was 20.1% (n=1427/7110) and 9.9% (n=477/4842) in males and females, respectively. After adjusting for other variables, metabolic syndrome (OR 1.26; 95% CI 1.09 to 1.45) but not NAFLD (OR 1.14; 95% CI 0.98 to 1.30) significantly correlated with erosive oesophagitis in males, while NAFLD (OR 1.50; 95% CI 1.21 to 1.86) but not metabolic syndrome (OR 1.24; 95% CI 0.94 to 1.63) positively correlated with erosive oesophagitis in females. Conclusions The detrimental effect on erosive oesophagitis is greater by metabolic syndrome than by NAFLD in males but greater by NAFLD than by metabolic syndrome in females.

AB - Objectives Although metabolic syndrome correlates with erosive oesophagitis, few studies have examined the association between non-alcoholic fatty liver disease (NAFLD), associated with obesity and insulin resistance as metabolic syndrome, and erosive oesophagitis. The possible gender differences in risk factors of erosive oesophagitis should be considered. This study aimed to determine the concomitant effects of NAFLD and metabolic syndrome on erosive oesophagitis with respect to gender. Design, setting, participants and outcome measures This cross-sectional study, conducted between January 2000 and August 2009, included 12090 participants from the health examination center of a tertiary hospital. NAFLD was diagnosed according to ultrasonographic findings after excluding participants with excessive alcohol consumption or other liver diseases. Metabolic syndrome was determined using the revised National Cholesterol Education Program Adult Treatment Panel III criteria. Erosive oesophagitis was defined according to the Los Angeles classification by oesophagogastroduodenoscopy. Results On the basis of the oesophagogastroduodenoscopic findings, the prevalence of erosive oesophagitis was 20.1% (n=1427/7110) and 9.9% (n=477/4842) in males and females, respectively. After adjusting for other variables, metabolic syndrome (OR 1.26; 95% CI 1.09 to 1.45) but not NAFLD (OR 1.14; 95% CI 0.98 to 1.30) significantly correlated with erosive oesophagitis in males, while NAFLD (OR 1.50; 95% CI 1.21 to 1.86) but not metabolic syndrome (OR 1.24; 95% CI 0.94 to 1.63) positively correlated with erosive oesophagitis in females. Conclusions The detrimental effect on erosive oesophagitis is greater by metabolic syndrome than by NAFLD in males but greater by NAFLD than by metabolic syndrome in females.

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U2 - 10.1136/bmjopen-2016-013106

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