Generation of Ca-Alginate Microcapsules with Different Concentrations in a Microfluidic Fusion Chip

Wei Chien Weng, Shen Yang Lin, Chia Hsien Yeh, I. Yu Huang, Yu-Cheng Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a micro fluidic fusion chip for generating Ca-alginate microcapsules with different concentrations. Using MEMS technology, we designed and fabricated a PDMS microfluidic chip, which contained a micron rating 3D electrode as a replacement for the planar electrode made of indium tin oxide, a pillar-induced fusion zone, and an s-shaped observation zone. We used this microfluidic chip to generate Ca-alginate microcapsules uniformly sized but covered in different bovine serum albumin (BSA) concentrations, and found that the sizes ranged between \mathbf{181\ \mu \mathrm{m}} and \mathbf{161\ \mu \mathrm{m}}. After putting the three differently-sized microcapsules and three different BSA concentrations into Phosphate Buffered Saline for drug release, we observed through the UV IVisible Absorption Spectrometer that the Ca-alginate generated by microfluidic chip could release different drug concentrations at the same time. Thus, the proposed microfluidic chip can be applied to producing microcapsules of different sizes and with different drug concentrations.

Original languageEnglish
Title of host publication2018 IEEE SENSORS, SENSORS 2018 - Conference Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538647073
DOIs
Publication statusPublished - 2018 Dec 26
Event17th IEEE SENSORS Conference, SENSORS 2018 - New Delhi, India
Duration: 2018 Oct 282018 Oct 31

Publication series

NameProceedings of IEEE Sensors
Volume2018-October
ISSN (Print)1930-0395
ISSN (Electronic)2168-9229

Conference

Conference17th IEEE SENSORS Conference, SENSORS 2018
CountryIndia
CityNew Delhi
Period18-10-2818-10-31

Fingerprint

Alginate
Microfluidics
Fusion reactions
Electrodes
Fluidics
Tin oxides
Indium
MEMS
Spectrometers
Phosphates

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

Cite this

Weng, W. C., Lin, S. Y., Yeh, C. H., Huang, I. Y., & Lin, Y-C. (2018). Generation of Ca-Alginate Microcapsules with Different Concentrations in a Microfluidic Fusion Chip. In 2018 IEEE SENSORS, SENSORS 2018 - Conference Proceedings [8589831] (Proceedings of IEEE Sensors; Vol. 2018-October). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICSENS.2018.8589831
Weng, Wei Chien ; Lin, Shen Yang ; Yeh, Chia Hsien ; Huang, I. Yu ; Lin, Yu-Cheng. / Generation of Ca-Alginate Microcapsules with Different Concentrations in a Microfluidic Fusion Chip. 2018 IEEE SENSORS, SENSORS 2018 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. (Proceedings of IEEE Sensors).
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Weng, WC, Lin, SY, Yeh, CH, Huang, IY & Lin, Y-C 2018, Generation of Ca-Alginate Microcapsules with Different Concentrations in a Microfluidic Fusion Chip. in 2018 IEEE SENSORS, SENSORS 2018 - Conference Proceedings., 8589831, Proceedings of IEEE Sensors, vol. 2018-October, Institute of Electrical and Electronics Engineers Inc., 17th IEEE SENSORS Conference, SENSORS 2018, New Delhi, India, 18-10-28. https://doi.org/10.1109/ICSENS.2018.8589831

Generation of Ca-Alginate Microcapsules with Different Concentrations in a Microfluidic Fusion Chip. / Weng, Wei Chien; Lin, Shen Yang; Yeh, Chia Hsien; Huang, I. Yu; Lin, Yu-Cheng.

2018 IEEE SENSORS, SENSORS 2018 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. 8589831 (Proceedings of IEEE Sensors; Vol. 2018-October).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Weng WC, Lin SY, Yeh CH, Huang IY, Lin Y-C. Generation of Ca-Alginate Microcapsules with Different Concentrations in a Microfluidic Fusion Chip. In 2018 IEEE SENSORS, SENSORS 2018 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc. 2018. 8589831. (Proceedings of IEEE Sensors). https://doi.org/10.1109/ICSENS.2018.8589831