Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City, Vietnam, 2011

Le Phan Kim Thoa; Pai Shan Chiang; Truong Huu Khanh; Shu Ting Luo; Tran Ngoc Hanh Dan; Ya Fang Wang; Tang Chi Thuong; Wan Yu Chung; Nguyen Thanh Hung; Jen Ren Wang; Le Nguyen Thanh Nhan; Le Quoc Thinh; Ih Jen Su; Than Duc Dung; Min Shi Lee

doi:10.1371/journal.pone.0069895

Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City, Vietnam, 2011

Le Phan Kim Thoa, Pai Shan Chiang, Truong Huu Khanh, Shu Ting Luo, Tran Ngoc Hanh Dan, Ya Fang Wang, Tang Chi Thuong, Wan Yu Chung, Nguyen Thanh Hung, Jen Ren Wang, Le Nguyen Thanh Nhan, Le Quoc Thinh, Ih Jen Su, Than Duc Dung, Min Shi Lee

Department of Medical Laboratory Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formulate vaccination policy in Vietnam.

Original language	English
Article number	e69895
Journal	PloS one
Volume	8
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0069895
Publication status	Published - 2013 Jul 29

All Science Journal Classification (ASJC) codes

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Thoa, L. P. K., Chiang, P. S., Khanh, T. H., Luo, S. T., Dan, T. N. H., Wang, Y. F., Thuong, T. C., Chung, W. Y., Hung, N. T., Wang, J. R., Nhan, L. N. T., Thinh, L. Q., Su, I. J., Dung, T. D., & Lee, M. S. (2013). Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City, Vietnam, 2011. PloS one, 8(7), Article e69895. https://doi.org/10.1371/journal.pone.0069895

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abstract = "Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formulate vaccination policy in Vietnam.",

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AU - Lee, Min Shi

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Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City, Vietnam, 2011

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