Genetic pathway of major depressive disorder in shortening telomeric length

For Wey Lung, Nathan C. Chen, Bih-Ching Shu

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

CONTEXT: Shortened telomeric length has been associated with aging and monoamine oxidase A gene activity. The pathways of genetic activity and mental disorder in shortening telomeric length, however, remain unclear. OBJECTIVE: The purpose of this study was to explore the possible pathways of the monoamine oxidase A promoter, ApoE polymorphisms and telomeric length in major depressive disorder. METHODS: This study enrolled 253 unrelated patients with major depression in southern Taiwan, and was carried out between March 2001 and September 2004. In addition, 411 controls were randomly selected from the general population in southern Taiwan. RESULTS: Hierarchical regression showed that the influence of the monoamine oxidase A promoter and ApoE2 polymorphisms was not statistically significant to telomeric length, when additionally adjusting for major depressive disorder. A final robust structural equation model showed that aging and major depressive disorder both have a statistically significant shortening effect on telomeric length. Moreover, sex, the Apoε2 allele, and the monoamine oxidase A promoter polymorphism have indirect effects on telomeric length. CONCLUSION: Major depressive disorder is a mediating factor between the monoamine oxidase A promoter polymorphism and telomeric length.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalPsychiatric Genetics
Volume17
Issue number3
DOIs
Publication statusPublished - 2007 Jun 1

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Monoamine Oxidase
Major Depressive Disorder
Taiwan
Apolipoprotein E2
Inborn Genetic Diseases
Structural Models
Apolipoproteins E
Mental Disorders
Alleles
Depression
Population
Genes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Lung, For Wey ; Chen, Nathan C. ; Shu, Bih-Ching. / Genetic pathway of major depressive disorder in shortening telomeric length. In: Psychiatric Genetics. 2007 ; Vol. 17, No. 3. pp. 195-199.
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Genetic pathway of major depressive disorder in shortening telomeric length. / Lung, For Wey; Chen, Nathan C.; Shu, Bih-Ching.

In: Psychiatric Genetics, Vol. 17, No. 3, 01.06.2007, p. 195-199.

Research output: Contribution to journalArticle

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AB - CONTEXT: Shortened telomeric length has been associated with aging and monoamine oxidase A gene activity. The pathways of genetic activity and mental disorder in shortening telomeric length, however, remain unclear. OBJECTIVE: The purpose of this study was to explore the possible pathways of the monoamine oxidase A promoter, ApoE polymorphisms and telomeric length in major depressive disorder. METHODS: This study enrolled 253 unrelated patients with major depression in southern Taiwan, and was carried out between March 2001 and September 2004. In addition, 411 controls were randomly selected from the general population in southern Taiwan. RESULTS: Hierarchical regression showed that the influence of the monoamine oxidase A promoter and ApoE2 polymorphisms was not statistically significant to telomeric length, when additionally adjusting for major depressive disorder. A final robust structural equation model showed that aging and major depressive disorder both have a statistically significant shortening effect on telomeric length. Moreover, sex, the Apoε2 allele, and the monoamine oxidase A promoter polymorphism have indirect effects on telomeric length. CONCLUSION: Major depressive disorder is a mediating factor between the monoamine oxidase A promoter polymorphism and telomeric length.

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