Genetic susceptibility to lung cancer

Haruhiko Sugimura, Hong Tao, Masaya Suzuki, Hiroki Mori, Masaru Tsuboi, Shun Matsuura, Masanori Goto, Kazuya Shinmura, Takachika Ozawa, Fumihiko Tanioka, Naomi Sato, Yoshitaka Matsushima, Shinji Kageyama, Kazuhito Funai, Pei Hsin Chou, Tomonari Matsuda

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Lung cancer is a highly environmental disease, but cancer researchers have long been interested in investigating genetic susceptibility to lung cancer. This paper is a historical review and provides updated perspectives on lung cancer susceptibility research. The recent introduction of easier genotyping methods and the availability of an almost complete human genome database facilitated the association study to thousands of cases and controls for millions of genetic markers. Discoveries in the field of behavior genetics, that is, the genetic aspects of smoking behavior and nicotine addiction, unexpectedly indicated that polymorphisms in the human central nervous system play an important role in eventually leading to lung cancer. These findings were achieved by using comprehensive approaches, such as a genome, transcriptome, or proteome approach, and the studies were often conducted without a hypothesis. Another-omics approach, the "adductome" or "exposome" approach to how life style information can be integrated into the framework of genetic association studies, has recently emerged. These new paradigms will influence the area of lung cancer risk evaluation in genome cohort studies.

Original languageEnglish
Pages (from-to)1463-1477
Number of pages15
JournalFrontiers in Bioscience - Scholar
Volume3 S
Issue number4
Publication statusPublished - 2011 Jun 1

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology


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